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Program
Oral Presentation
Introduction : 5 min
Invited talks : 25 min (20 min presentation and 5 min discussion)
Poster talks : 15 min (12 min presentation and 3 min discussion)
Poster Presentation
Poster size is 90 cm in width and 180 cm in height.
| October 5 (Sunday)
|
| 15:00 - 19:00 | Registration |
| 19:00 - 21:00 | Reception |
| October 6 (Monday)
|
|
~ Breakfast ~ |
|
| Opening Remarks | 8:20 - 8:30 | Yoshinori Shichida (Kyoto University) |
| I. Theory for retinal proteins (Chair: Massimo Olivucci and Shigehiko Hayashi) | |
| 8:30 - 8:35 | Introduction by Massimo Olivucci (Bowling Green State University, USA) |
| S1-1 8:35 - 9:00 |
Shigehiko Hayashi (Kyoto University, Japan) Understanding and designing color variants of retinal biding proteins by molecular simulations |
| S1-2 9:00 - 9:25 |
Sivakumar Sekharan (Yale University, USA) Computational studies of retinal proteins and olfactory receptors |
| S1-3 9:25 - 9:40 |
Hiroshi C. Watanabe (Tokyo Institute of Technology, Japan) Theoretical approach toward an understanding of molecular functions of channelrhodopsin |
| S1-4 9:40 - 10:05 |
James H. Geiger (Michigan State University, USA) Decoding color vision: Understanding protein/chromophore interactions using a rhodopsin mimic and developing novel protein fusion tags |
| S1-5 10:05 - 10:30 |
Massimo Olivucci (Bowling Green State University, USA) Comparison of the isomerization mechanisms of microbial, invertebrate and vertebrate light-sensing rhodopsins |
| ~ Coffee Break ~ |
| II. New and extended techniques (Chair: Mordechai Sheves and Yuji Furutani) | |
| 11:00 - 11:05 | Introduction by Mordechai Sheves (The Weizmann Institute of Science, Israel) |
| S2-1 11:05 - 11:30 |
Tahei Tahara (RIKEN, Japan) Femtosecond time-resolved impulsive stimulated Raman study of photoactive yellow protein |
| S2-2 11:30 - 11:55 |
Philipp Kukura (University of Oxford, UK) Unravelling the origin of retinal reactivity in rhodopsins: A combined synthetic and ultrafast approach |
| S2-3 11:55 - 12:10 |
Tom Resler (Freie Universitaet Berlin, Germany) Deuterium isotope effects on channelrhodopsin-2 |
| S2-4 12:10 - 12:35 |
Yuji Furutani (Institute for Molecular Science, Japan) Structural changes of membrane proteins studied by difference FTIR spectroscopy; microbial rhodopsins and potassium ion channels |
| S2-5 12:35 - 13:00 |
Takayuki Uchihashi (Kanazawa University, Japan) Single-molecule imaging of proteins at work with high-speed atomic force microscopy |
| ~ Lunch ~ |
| III. Structure of animal rhodopsins and GPCRs (Chair: Gebhard Schertler and Midori Murakami) | |
| 14:30 - 14:35 | Introduction by Gebhard F. X. Schertler (Paul Scherrer Institut, Switzerland) |
| S3-1 14:35 - 15:00 |
Jörg Standfuss (Paul Scherrer Institut, Switzerland) Structures of rhodopsin mutants that cause night blindness and retina degeneration |
| S3-2 15:00 - 15:15 |
Blake Mertz (West Virginia University, USA) Validating the retinal flip of rhodopsin using molecular dynamics |
| S3-3 15:15 - 15:40 |
Martha E. Sommer (Charité-Universitätsmedizin Berlin, Germany) The functional versatility of arrestin in the visual system |
| S3-4 15:40 - 16:05 |
Ichio Shimada (The University of Tokyo, Japan) Functional equilibrium of membrane proteins by NMR |
| S3-5 16:05 - 16:30 |
Yoshinori Fujiyoshi (Nagoya University, Japan) Structures of cell adhesive-channels |
| ~ Coffee Break ~ |
| IV. Structure of microbial rhodopsins (Chair: Leonid S. Brown and Tsutomu Kouyama) | |
| 17:00 - 17:05 | Introduction by Leonid S. Brown (University of Guelph, Canada) |
| S4-1 17:05 - 17:30 |
Tsutomu Kouyama (Nagoya University, Japan) Conformational changes in helices C and F of pharaonis halorhodopsin during the ion pumping cycle |
| S4-2 17:30 - 17:55 |
Valentin I. Gordeliy (Institut de Biologie Structurale, France) New insights on molecular mechanisms of ion pumping and signal transduction in retinal proteins |
| S4-3 17:55 - 18:20 |
Osamu Nureki (The University of Tokyo, Japan) Molecular processes underlying the early stages of channel opening in channelrhodopsin and its structure-based engineering |
| S4-4 18:20 - 18:35 |
Takeshi Murata (Chiba University, Japan) X-ray crystal structure of the proton pumping rhodopsin TR from the hyperthermoplile Thermus thermophilus |
| S4-5 18:35 - 19:00 |
Vladimir Ladizhansky (University of Guelph, Canada) Structure, oligomerization and dynamics of Anabaena sensory rhodopsin in the lipid environments |
| ~ Dinner ~ |
| 21:00 - 23:00 | Poster |
| 23:00 - | Free Discussion |
| October 7 (Tuesday)
|
|
~ Breakfast ~ |
|
| V. Pump rhodopsin (Chair: Klaus Gerwert and Hideki Kandori) | |
| 8:30 - 8:35 | Introduction by Hideki Kandori (Nagoya Institute of Technology, Japan) |
| S5-1 8:35 - 9:00 |
Klaus Gerwert (Ruhr-Universität Bochum, Germany) Bacteriorhodopsin and channelrhodopsin: E90 makes the difference between a pump and a channel |
| S5-2 9:00 - 9:25 |
Ana-Nicoleta Bondar (Free University of Berlin, Germany) Hydrogen bond dynamics and directional proton transfers in microbial rhodopsins |
| S5-3 9:25 - 9:40 |
Sergei P. Balashov (University of California, Irvine, USA) Novel properties of the proton pump from Exiguobacterium sibiricum |
| S5-4 9:40 - 10:05 |
Keiichi Inoue (Nagoya Institute of Technology, Japan) Function and molecular mechanism of sodium pump rhodopsin |
| S5-5 10:05 - 10:30 |
Janos K. Lanyi (University of California, Irvine, USA) Na+ transport in a light-driven pump from Gillisia limnaea |
| ~ Coffee Break ~ |
| VI. Signal rhodopsin (Chair: Joachim Heberle and Makoto Demura) | |
| 11:00 - 11:05 | Introduction by Joachim Heberle (Freie Universität Berlin, Germany) |
| S6-1 11:05 - 11:30 |
Leonid S. Brown (University of Guelph, Canada) New insights into eubacterial rhodopsins - from bioinformatics to spectroscopy |
| S6-2 11:30 - 11:55 |
Akira Naito (Yokohama National University, Japan) Detection of photo-intermediates of microbial sensory rhodopsins by in situ photo-irradiation solid-state NMR |
| S6-3 11:55 - 12:20 |
Hideki Kandori (Nagoya Institute of Technology, Japan) FTIR study of signaling microbial rhodopsins |
| S6-4 12:20 - 12:45 |
Víctor A. Lórenz-Fonfría (Freie Universität Berlin, Germany) Protonation and conformation changes in channelrhodopsin-2 and their relevance in channel gating |
| S6-5 12:45 - 13:00 |
Kirstin Eisenhauer (Ruhr-University Bochum, Germany)(br>
Homology models of channelrhodopsin-2: The closed and open form of the channel
|
| ~ Lunch ~ |
| VII. New aspects in microbial rhodopsins (Chair: Janos Lanyi and Akira Naito) | |
| 14:30 - 14:35 | Introduction by Akira Naito (Yokohama National University, Japan) |
| S7-1 14:35 - 15:00 |
Sandy Ruhman (Hebrew University, Israel) Ultrafast studies of light harvesting and photochemistry in microbial retinal proteins |
| S7-2 15:00 - 15:25 |
Yasuhisa Mizutani (Osaka University, Japan) Structure changes of microbial rhodopsins in their photocycles as revealed by time-resolved visible and ultraviolet resonance Raman spectroscopy |
| S7-3 15:25 - 15:50 |
Christian Bamann (Max-Planck-Institut für Biophysik, Germany) Structural and mechanistic aspects of channelrhodopsins |
| S7-4 15:50 - 16:15 |
Makoto Demura (Hokkaido University, Japan) Analyses of Cl–-pumping photocycle of halorhodopsin |
| S7-5 16:15 - 16:30 |
Li-Kang Chu (National Tsing Hua University, Taiwan) Photochemistry of a dual-bacteriorhodopsin system in Haloarcula marismortui: HmbRI and HmbRII |
| ~ Coffee Break ~ |
| VIII. Animal rhodopsins (Chair: Klaus-Peter Hofmann and Shuji Tachibanaki) | |
| 17:00 - 17:05 | Introduction by Klaus-Peter Hofmann (Charité-Universitätsmedizin Berlin, Germany) |
| S8-1 17:05 - 17:30 |
Elsa Yan (Yale University, USA) Role of rhodopsin’s unusual kinetics of thermal reactions in dim-light vision |
| S8-2 17:30 - 17:55 |
Yasushi Imamoto (Kyoto University, Japan) Single-molecule observation of the ligand-induced population shift of rhodopsin, a G-protein coupled receptor |
| S8-3 17:55 - 18:20 |
Shuji Tachibanaki (Osaka University, Japan) Different efficiencies of enzymatic reactions in the phototransduction cascade between carp rods and cones |
| S8-4 18:20 - 18:45 |
Oliver Ernst (University of Toronto, Canada) Rhodopsin conformational states in solution and their phospholipid scramblase activity |
| S8-5 18:45 - 19:00 |
Hisao Tsukamoto (Institute of Molecular Science, Japan) Energetics and conformational dynamics underlying the activation of the G protein-coupled receptor opsin assessed by site-directed fluorescence labeling and nanodisc techniques |
| ~ Dinner ~ |
| 21:00 - 23:00 | Poster |
| 23:00 - | Free Discussion |
| October 8 (Wednesday)
|
|
~ Breakfast ~ |
|
| IX. Non-visual opsins (Chair: Yoshitaka Fukada and Michael Do) | |
| 8:30 - 8:35 | Introduction by Yoshitaka Fukada (The University of Tokyo, Japan) |
| S9-1 8:35 - 9:00 |
Kristin Tessmar-Raible (University of Vienna, Austria)
More than meets the eye: Non-visual photoreceptors in vertebrates and moonstruck bristle worms
|
| S9-2 9:00 - 9:25 |
Daisuke Kojima (The University of Tokyo, Japan) Photoreceptors regulating background adaptation in zebrafish |
| S9-3 9:25 - 9:50 |
Akihisa Terakita (Osaka City University, Japan) Molecular basis of wavelength discrimination in the pineal organs of lower vertebrates |
| S9-4 9:50 - 10:15 |
Michael Do (Harvard University, USA) Melanopsin tristability for sustained and broadband phototransduction |
| S9-5 10:15 - 10:30 |
Take Matsuyama (Kyoto University, Japan) Signaling of melanopsin, a tristable pigment |
| ~ Coffee Break ~ |
| X. New aspects of opsins and GPCRs (Chair: Thomas P. Sakmar and Yasushi Imamoto) | |
| 11:00 - 11:05 | Introduction by Thomas P. Sakmar (The Rockefeller University, USA) |
| S10-1 11:05 - 11:30 |
Thomas P. Sakmar (The Rockefeller University, USA) Bioorthogonal labeling of rhodopsin to facilitate functional studies |
| S10-2 11:30 - 11:55 |
Takahiro Yamashita (Kyoto University, Japan) Molecular properties of vertebrate non-visual opsin, Opn5 |
| S10-3 11:55 - 12:20 |
Mitsumasa Koyanagi (Osaka City University, Japan) Molecular properties of diverse and engineered bistable pigments and their optogenetic potential |
| S10-4 12:20 - 12:45 |
David M. Hunt (University of Western Australia, Australia) Vision in ancient vertebrates: Evolution of visual pigments and associated components of phototransduction |
| S10-5 12:45 - 13:00 |
Toshiyuki Okano (Waseda University, Japan) Ocular clock in the light: Photic induction and circadian oscillation of mRNAs in the fish ocular cells |
| ~ Lunch ~ |
| Excursion | |
| Lunch (Bento) |
|
| Hikone Castle |
|
| Sake (Japanese rice wine) cellar and brewery
(Movie) |
|
| ~ Dinner ~ |
| 21:00 - 23:00 | Poster |
| 23:00 - | Free Discussion |
| October 9 (Thursday)
|
|
~ Breakfast ~ |
|
| XI. PYP and flavin proteins (Chair: Joachim Heberle and Mikio Kataoka) | |
| 8:30 - 8:35 | Introduction by Joachim Heberle (Freie Universität Berlin, Germany) |
| S11-1 8:35 - 9:00 |
Mikio Kataoka (Nara Institute of Science and Technology, Japan) Structure and photoreaction of photoactive yellow protein |
| S11-2 9:00 - 9:25 |
Andrew Woolley (University of Toronto, Canada) Engineering photoactive yellow protein |
| S11-3 9:25 - 9:50 |
Wouter D. Hoff (Oklahoma State University, USA) Using photoactive yellow protein as a model system for obtaining generally applicable insights into protein biophysics |
| S11-4 9:50 - 10:15 |
Masahide Terazima (Kyoto University, Japan) Photosensing reaction dynamics of flavin proteins: Phototropin |
| S11-5 10:15 - 10:30 |
Osamu Hisatomi (Osaka University, Japan) A photo-activated basic-leucine zipper module, opZL |
| ~ Coffee Break ~ |
| XII. Tools for optogenetics (Chair: Peter Hegemann and Yuki Sudo) | |
| 11:00 - 11:05 | Introduction by Peter Hegemann (Humboldt-University, Germany) |
| S12-1 11:05 - 11:30 |
Peter Hegemann (Humboldt-University, Germany) Biophysics of channelrhodopsin |
| S12-2 11:30 - 11:55 |
Yuki Sudo (Okayama University, Japan) Molecular-based rational design and engineering of microbial retinal proteins for optogenetics |
| S12-3 11:55 - 12:20 |
Michel Vivaudou (Centre National de la Recherche Scientifique, France) Natural and artificial coupling of opsin to potassium channels |
| S12-4 12:20 - 12:45 |
Takeharu Nagai (Osaka University, Japan) Genetically-encoded tools to optically control and image Ca2+ dynamics |
| S12-5 12:45 - 13:00 |
Shoko Hososhima (Tohoku University, Japan) Bi-stable variants of chimeric channelrhodopsins - kinetics-dependent activation of neurons |
| 13:00 - 13:10 | Group Photo |
| ~ Lunch ~ |
| XIII. Controlling animal behavior (Chair: Robert J. Lucas and Akihisa Terakita) | |
| 14:30 - 14:35 | Introduction by Akihisa Terakita (Osaka City University, Japan) |
| S13-1 14:35 - 15:00 |
Robert J. Lucas (University of Manchester, UK) Optogenetic application of animal opsins |
| S13-2 15:00 - 15:25 |
Hiromu Yawo (Tohoku University, Japan) Optogenetic patterning of touch perception-sensing light by skin |
| S13-3 15:25 - 15:50 |
Narasimhan Gautam (Washington University, USA) Subcellular optogenetics: Controlling signaling and cell behavior |
| S13-4 15:50 - 16:15 |
Akihiro Yamanaka (Nagoya University, Japan) Regulatory mechanism of sleep/wakefulness revealed by using optogenetics |
| S13-5 16:15 - 16:30 |
Satoshi Tsunoda (Goethe-University, Germany) Optogenetic manipulation of behavior by newly engineered channelrhodopsin variants in C. elegans |
| ~ Coffee Break ~ |
| XIV. Visual cycle (Chair: Rosalie Crouch and Satoru Kawamura) | |
| 17:00 - 17:05 | Introduction by Satoru Kawamura (Osaka University, Japan) |
| S14-1 17:05 - 17:30 |
Satoru Kawamura (Osaka University, Japan) AL-OL coupling reaction, a possible mechanism of visual pigment regeneration in carp cones |
| S14-2 17:30 - 17:55 |
Yiannis Koutalos (Medical University of South Carolina, USA) Following vitamin A metabolites in single photoreceptor cells |
| S14-3 17:55 - 18:20 |
Vladimir Kefalov (Washington University in St. Louis, USA) Can rods regenerate their pigment without the RPE? |
| S14-4 18:20 - 18:35 |
Minghao Jin (Louisiana State University Health Sciences Center, USA) The 26S proteasome non-ATPase regulatory subunit 13 (PSMD13) mediates rapid degradation of disease-associated mutant RPE65 proteins via the ubiquitin-proteasome pathway |
| S14-5 18:35 - 19:00 |
Rosalie Crouch (Medical University of South Carolina, USA) Lack of correlation of A2E and other bis-retinoids with lipofuscin in the human RPE |
| Closing Remarks | 19:00 - 19:10 | Yoshinori Shichida (Kyoto University) |
19:30 - 21:30 |
Banquet |
| 21:30 - 23:00 | Poster |
| 23:00 - | Free Discussion |
| October 10 (Friday)
|
|
~ Breakfast ~ |
|
Free Discussion & Closing |