2013

Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function

Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function
Baba K, Benleulmi-Chaachoua A, Journé AS, Kamal M, Guillaume JL, Dussaud S, Gbahou F, Yettou K, Liu C, Contreras-Alcantara S, Jockers R, Tosini G.
Sci Signal 2013 Oct 8;6(296)

Detection of single photons by toad and mouse rods

Detection of single photons by toad and mouse rods.
Reingruber J, Pahlberg J, Woodruff ML, Sampath AP, Fain GL, Holcman D.
PNAS2013 Nov 26;110(48):19378-83

Adaptation to steady light by intrinsically photosensitive retinal ganglion cells

Adaptation to steady light by intrinsically photosensitive retinal ganglion cells.
Do MT, Yau KW.
PNAS2013 Apr 30;110(18):7470-5.

Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells

Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells
Kiyonaka S, Kajimoto T, Sakaguchi R, Shinmi D, Omatsu-Kanbe M, Matsuura H, Imamura H, Yoshizaki T, Hamachi I, Morii T, Mori Y.
Nat Methods2013 Oct 13

Optogenetic control of targeted peripheral axons in freely moving animals

Optogenetic control of targeted peripheral axons in freely moving animals
Towne C, Montgomery KL, Iyer SM, Deisseroth K, Delp SL.
PLoS One2013 Aug 21;8(8)

Small-molecule antagonists of melanopsin-mediated phototransduction

Small-molecule antagonists of melanopsin-mediated phototransduction
Jones KA, Hatori M, Mure LS, Bramley JR, Artymyshyn R, Hong SP, Marzabadi M, Zhong H, Sprouse J, Zhu Q, Hartwick AT, Sollars PJ, Pickard GE, Panda S.
Nat Chem Biol2013 Oct;9(10):630-5

Structure of Arrestin

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide
Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ
Nature2013 May 2;497(7447):137-41

Crystal structure of pre-activated arrestin p44
Kim YJ, Hofmann KP, Ernst OP, Scheerer P, Choe HW, Sommer ME
Nature2013 May 2;497(7447):142-6

Fly cryptochrome and the visual system

Fly cryptochrome and the visual system
Gabriella Mazzotta, Alessandro Rossi, Emanuela Leonardi, Moyra Mason, Cristiano Bertolucci, Laura Caccin, Barbara Spolaore, Alberto J. M. Martin, Matthias Schlichting, Rudi Grebler, Charlotte Helfrich-Förster, Stefano Mammi, Rodolfo Costa, Silvio C. E. Tosatto
Proc Natl Acad Sci U S A2013 April 9; 110(15): 6163–6168.

VAL・TMT opsins expressed in interneurons

Co-Expression of VAL- and TMT-Opsins Uncovers Ancient Photosensory Interneurons and Motorneurons in the Vertebrate Brain.
Fischer RM, Fontinha BM, Kirchmaier S, Steger J, Bloch S, Inoue D, Panda S, Rumpel S, Tessmar-Raible K.
PLoS Biol　2013 Jun;11(6).

Rhodopsin dimer assymetry: Complex with Gt and Arrestin

The rhodopsin-transducin complex houses two distinct rhodopsin molecules.
Jastrzebska B, Ringler P, Palczewski K, Engel A.
J Struct Biol　2013 May;182(2):164-72.

Distinct loops in arrestin differentially regulate ligand binding within the GPCR opsin.
Sommer ME, Hofmann KP, Heck M.
Nat Commun 2012;3:995

How we sense saltyness

High salt recruits aversive taste pathways.
Oka Y, Butnaru M, von Buchholtz L, Ryba NJ, Zuker CS.
Nature 2013 Feb 28;494(7438):472-5.

tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans.
Chatzigeorgiou M, Bang S, Hwang SW, Schafer WR.
Nature 2013 Feb 7;494(7435):95-9

Molecular sensor using fluorophores linked by ER/K motif and application of it for GPCR analysis

Malik RU, Ritt M, Devree BT, Neubig RR, Sunahara RK, Sivaramakrishnan S.(2013) Detection of G-protein selective G-protein Coupled Receptor (GPCR) conformations in live cells. J Biol Chem. 2013 Apr 29. (Epub)

Sivaramakrishnan S, Spudich JA.(2011) Systematic control of protein interaction using a modular ER/K α-helix linker. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20467-72.

Molecular and cellular mechanism of nonvisual photomotor response of embryonic zebrafish

Kokel D, Dunn TW, Ahrens MB, Alshut R, Cheung CY, Saint-Amant L, Bruni G, Mateus R, van Ham TJ, Shiraki T, Fukada Y, Kojima D, Yeh JR, Mikut R, von Lintig J, Engert F, Peterson RT.(2013) Identification of nonvisual photomotor response cells in the vertebrate hindbrain. J Neurosci. 2013 Feb 27;33(9):3834-43.

GPCR signaling via beta-arrestin

Wehbi VL, Stevenson HP, Feinstein TN, Calero G, Romero G, Vilardaga JP.(2013) Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complex. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1530-5.

Li B, Wang C, Zhou Z, Zhao J, Pei G.(2013) β-Arrestin-1 directly interacts with Gαs and regulates its function. FEBS Lett. 2013 Mar 1;587(5):410-6.

Experimental application of rhodopsins

Barish PA, Xu Y, Li J, Sun J, Jarajapu YP, Ogle WO.(2013) Design and functional evaluation of an optically active μ-opioid receptor. Eur J Pharmacol. 2013 Feb 27;705(1-3):42-48.

Maclaurin D, Venkatachalam V, Lee H, Cohen AE.(2013) Mechanism of voltage-sensitive fluorescence in a microbial rhodopsin. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5939-44.

Utilization of CRISPR/Cas, the immune system of bacteria and archaea for gene editing

Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F.(2013) Multiplex genome engineering using CRISPR/Cas systems. Science. 2013 Feb 15;339(6121):819-23.

Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM.(2013) RNA-guided human genome engineering via Cas9. Science. 2013 Feb 15;339(6121):823-6.

Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E.(2012) A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science. 2012 Aug 17;337(6096):816-21.

Phylogenetic analysis of Calcium-binding luminescent proteins, Photoproteins and opsins of ctenophore

Schnitzler CE, Pang K, Powers ML, Reitzel AM, Ryan JF, Simmons D, Tada T, Park M, Gupta J, Brooks SY, Blakesley RW, Yokoyama S, Haddock SH, Martindale MQ, Baxevanis AD.(2012) Genomic organization, evolution, and expression of photoprotein and opsin genes in Mnemiopsis leidyi: a new view of ctenophore photocytes. BMC Biol. 2012 Dec 21;10:107.

Light-mediated control of rhodopsin movement in mosquito photoreceptors.

Hu X, Leming MT, Metoxen AJ, Whaley MA, O'Tousa JE.(2012) Light-mediated control of rhodopsin movement in mosquito photoreceptors. J Neurosci. 2012 Oct 3;32(40):13661-7

Intrinsic photosensitive RGC (ipRGC) affects light-dependent mood and learning.

LeGates TA, Altimus CM, Wang H, Lee HK, Yang S, Zhao H, Kirkwood A, Weber ET, Hattar S.(2012) Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature. 2012 Nov 22;491(7425):594-8.

Structural change of LOV or BLUF proteins by photon and application of them to optogenetics

Christie JM, Gawthorne J, Young G, Fraser NJ, Roe AJ.(2012) LOV to BLUF: flavoprotein contributions to the optogenetic toolkit. Mol Plant. 2012 May;5(3):533-44.

Mitra D, Yang X, Moffat K.(2012) Crystal structures of Aureochrome1 LOV suggest new design strategies for optogenetics. Structure. 2012 Apr 4;20(4):698-706.

Recent progress of the analyses of activation mechanism of metabotropic glutamate receptors (mGluRs)

El Moustaine D, Granier S, Doumazane E, Scholler P, Rahmeh R, Bron P, Mouillac B, Baneres JL, Rondard P, Pin JP.(2012) Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16342-7.

Hlavackova V, Zabel U, Frankova D, Batz J, Hoffmann C, Prezeau L, Pin JP, Blahos J, Lohse MJ.(2012) Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1. Sci Signal. 2012 Aug 14;5(237):ra59.