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2024

単一の光受容細胞による刺激の知覚と概日リズム調節への分割

A single photoreceptor splits perception and entrainment by cotransmission

Xiao N, Xu S, Li ZK, Tang M, Mao R, Yang T, Ma SX, Wang PH, Li MT, Sunilkumar A, Rouyer F, Cao LH, Luo DG.
Nature. 2023 Nov;623(7987):562-570. doi: 10.1038/s41586-023-06681-6. Epub 2023 Oct 25.

ipRGCサブタイプにおけるメラノプシンによる光伝達経路の多様性

Melanopsin activates divergent phototransduction pathways in intrinsically photosensitive retinal ganglion cell subtypes.

Contreras E, Bhoi JD, Sonoda T, Birnbaumer L, Schmidt TM.
Elife. 2023 Nov 8:12:e80749. doi: 10.7554/eLife.80749.

嗅細胞において１つの嗅覚受容体遺伝子のみが発現するしくみ

RNA-mediated symmetry breaking enables singular olfactory receptor choice.

Ariel D Pourmorady, Elizaveta V Bashkirova, Andrea M Chiariello, Houda Belagzhal, Albana Kodra, Rachel Duffié, Jerome Kahiapo, Kevin Monahan, Joan Pulupa, Ira Schieren, Alexa Osterhoudt, Job Dekker, Mario Nicodemi, Stavros Lomvardas
Nature. 2024 Jan;625(7993):181-188. doi: 10.1038/s41586-023-06845-4. Epub 2023 Dec 20.

REM睡眠中の辺縁系での活動による恐怖除去記憶の操作

Infralimbic activity during REM sleep facilitates fear extinction memory

Jiso Hong, Kyuhyun Choi, Marc V Fuccillo, Shinjae Chung, Franz Weber
Curr. Biol. 2024 Apr 27:S0960-9822(24)00458-5. doi: 10.1016/j.cub.2024.04.018.

眼と脳との間のリンパ系を介した免疫連関

Compartmentalized ocular lymphatic system mediates eye-brain immunity.

Xiangyun Yin, Sophia Zhang, Ju Hyun Lee, Huiping Dong, George Mourgkos, Gordon Terwilliger, Aurora Kraus, Luiz Henrique Geraldo, Mathilde Poulet, Suzanne Fischer, Ting Zhou Farrah Shalima Mohammed, Jiangbing Zhou, Yongfu Wang, Seth Malloy, Nicolas Rohner, Lokesh Sharma, Irene Salinas, Anne Eichmann, Jean-Leon Thomas, W Mark Saltzman, Anita Huttner, Caroline Zeiss, Aaron Ring, Akiko Iwasaki, Eric Song
Nature. 2024 Apr;628(8006):204-211. doi: 10.1038/s41586-024-07130-8. Epub 2024 Feb 28.

線虫の温覚神経ニューロンにおける適応とその機構

Feedforward and feedback mechanisms cooperatively regulate rapid experience-dependent response adaptation in a single thermosensory neuron type

Tyler J Hill, Piali Sengupta
Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2321430121. doi: 10.1073/pnas.2321430121. Epub 2024 Mar 26.

磁気受容に関わるCryptochrome 4 のラジカル生成メカニズム

Tracking the Electron Transfer Cascade in European Robin Cryptochrome 4 Mutants.

Timmer D, Frederiksen A, Lünemann DC, Thomas AR, Xu J, Bartölke R, Schmidt J, Kubař T, De Sio A, Solov'yov IA, Mouritsen H, Lienau C.
J Am Chem Soc. 2023 May 31;145(21):11566-11578. doi: 10.1021/jacs.3c00442. Epub 2023 May 17.

レチノイド異性化酵素の多様性

Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore.

Solano YJ, Everett MP, Dang KS, Abueg J, Kiser PD.
Nat Chem Biol. 2024 Jun;20(6):779-788. doi: 10.1038/s41589-024-01554-z. Epub 2024 Feb 14.

AlphaFold2構造の補助によるリガンド候補の探索

AlphaFold2 structures guide prospective ligand discovery

Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Álvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Glenn IS, Tummino TA, Huang S, Irwin JJ, Tarkhanova OO, Moroz Y, Skiniotis G, Kruse AC, Shoichet BK, Roth BL.
Science. 2024 Jun 21;384(6702):eadn6354. doi: 10.1126/science.adn6354. Epub 2024 Jun 21.

チャネルロドプシンの数種のリガンド結合パターン

Channelrhodopsins with distinct chromophores and binding patterns

Shan Y, Zhao L, Chen M, Li X, Zhang M, Pei D.
Nat Commun. 2024 Aug 24;15(1):7292. doi: 10.1038/s41467-024-51811-x.2024 Jun 21;384(6702):eadn6354. doi: 10.1126/science.adn6354. Epub 2024 Jun 21.

昆虫の赤外線感知メカニズムと生理的意義

Thermal infrared directs host-seeking behaviour in Aedes aegypti mosquitoes.

Chandel A, DeBeaubien NA, Ganguly A, Meyerhof GT, Krumholz AA, Liu J, Salgado VL, Montell C.
Nature. 2024 Sep;633(8030):615-623. doi: 10.1038/s41586-024-07848-5. Epub 2024 Aug 21.

機械学習の計算手法を用いた可溶性膜タンパク質のde novoデザイン

Computational design of soluble and functional membrane protein analogues

Casper A Goverde, Martin Pacesa, Nicolas Goldbach, Lars J Dornfeld, Petra E M Balbi, Sandrine Georgeon, Stéphane Rosset, Srajan Kapoor, Jagrity Choudhury, Justas Dauparas4, Christian Schellhaas, Simon Kozlov, David Baker, Sergey Ovchinnikov, Alex J Vecchio, Bruno E Correia
Nature. 2024 Jul;631(8020):449-458. doi: 10.1038/s41586-024-07601-y. Epub 2024 Jun 19.

複数本のAAVによる遺伝子導入手法の開発と、それを用いたマウスへの巨大transgeneの導入

Ribozyme-activated mRNA trans-ligation enables large gene delivery to treat muscular dystrophies

Sean R Lindley, Kadiam C Venkata Subbaiah, Fnu Priyanka, Pornthida Poosala, Yijie Ma, Leila Jalinous, Jason A West, William A Richardson, Tamlyn N Thomas, Douglas M Anderson
Nature. 2024 Nov 15;386(6723):762-767. doi: 10.1126/science.adp8179. Epub 2024 Nov 14.

線虫の光受容の多様性

cGMP-dependent pathway and a GPCR kinase are required for photoresponse in the nematode Pristionchus pacificus

Kenichi Nakayama, Hirokuni Hiraga, Aya Manabe, Takahiro Chihara, Misako Okumura
PLoS Genet. 2024 Nov 14;20(11):e1011320. doi: 10.1371/journal.pgen.1011320. eCollection 2024 Nov.

生体内光受容体塩基編集によるマウスのロドプシンE150K常染色体劣性網膜色素変性症の改善

In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice

Du SW, Newby GA, Salom D, Gao F, Menezes CR, Suh S, Choi EH, Chen PZ, Liu DR, Palczewski K.
Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2416827121. doi: 10.1073/pnas.2416827121. Epub 2024 Nov 18.