2025

Non-visual photoreceptive brain specification in sea urchin larvae

Yaguchi J, Tsuyuzaki K, Sawada I, Horiuchi A, Sakamoto N, Yamamoto T, Yamashita T, Yaguchi S
Nat. Commun.2025 Nov 19;16(1):10054. doi: 10.1038/s41467-025-65628-9. PMID: 41258319

プレスリリース

 

A key spectral tuning site of UV-sensitive vertebrate non-visual opsin Opn5

Yamashita T, Asamoto K, Fujii K, Fujiyabu C, Ohuchi H, Shichida Y
Cell. Mol. Life Sci. 2025 Sep 2;82(1):334. doi: 10.1007/s00018-025-05879-3. PMID: 40892281

 

Molecular diversity of protostome non-visual opsin arthropsin

Yamashita T, Fujii K, Fujiyabu C, Sakai K, Shiga Y
iScience 2025 Jun 24;28(7):112989. doi: 10.1016/j.isci.2025.112989. eCollection 2025 Jul 18. PMID: 40687782

 

A repertoire of visible light-sensitive opsins in the deep-sea hydrothermal vent shrimp Rimicaris hybisae

Nagata Y, Miyamoto N, Sato K, Nishimura Y, Tanioka Y, Yamanaka Y, Yoshizawa S, Takahashi K, Obayashi K, Tsukamoto H, Takai K, Ohuchi H, Yamashita T, Sudo Y, Kojima K
J. Biol. Chem. 2025 Jul;301(7):110291. doi: 10.1016/j.jbc.2025.110291. Epub 2025 May 26. PMID: 40436317

 

An extensive survey of vertebrate-specific, non-visual opsins identifies a novel subfamily, Q113-Bistable (QB) opsin

Gyoja F, Sato K, Yamashita T, Kusakabe TG
Genome Biol. Evol. 2025 Mar 6;17(3):evaf032. doi: 10.1093/gbe/evaf032. PMID: 40036976

 

Direct photoreception by pituitary endocrine cells regulates hormone release and pigmentation

Fukuda A, Sato K, Fujimori C, Yamashita T, Takeuchi A, Ohuchi H, Umatani C, Kanda S
Science 2025 Jan 3;387(6729):43-48. doi: 10.1126/science.adj9687. PMID:39745961

プレスリリース

 

Reviews and Other Publications

 

Yamashita T (2025) Discovery and design of photocyclic animal opsins: potential application to gene therapy from non-visual opsin research. Eye Vis (Lond), 12, 42.

山下高廣 (2025) 「光センサータンパク質からみた視覚の進化と多様性」 ファルマシア 61, 35-9.

 

2024

Light-modulated neural control of sphincter regulation in the evolution of through-gut

Yaguchi J, Sakai K, Horiuchi A, Yamamoto T, Yamashita T, Yaguchi S
Nat. Commun.2024 Oct 18;15(1):8881. doi: 10.1038/s41467-024-53203-7. PMID: 39424783

プレスリリース

 

Functional diversification process of opsin genes for teleost visual and pineal photoreceptions

Fujiyabu C, Gyoja F, Sato K, Kawano-Yamashita E, Ohuchi H, Kusakabe TG, Yamashita T
Cell Mol Life Sci. 2024 Oct 8;81(1):428. doi: 10.1007/s00018-024-05461-3. PMID: 39379743

プレスリリース

 

Convergent mechanism underlying the acquisition of vertebrate scotopic vision

Kojima K, Yanagawa M, Imamoto Y, Yamano Y, Wada A, Shichida Y, Yamashita T
J Biol. Chem. 2024 Mar 16;300(4):107175. doi: 10.1016/j.jbc.2024.107175. Online ahead of print. PMID: 38499150

 

Reviews and Other Publications

京都大学「医学領域」産学連携推進機構による紹介記事

 

2023

Mammalian type Opsin 5 preferentially activates G14 in Gq-type G proteins triggering intracellular calcium response

Sato K, Yamashita T, Ohuchi H
J Biol. Chem. 2023 Jul 7;105020. doi: 10.1016/j.jbc.2023.105020. Online ahead of print. PMID: 37423300

 

Diversification processes of teleost intron-less opsin genes

Fujiyabu C, Sato K, Ohuchi H, Yamashita T
J Biol. Chem. 2023 Jun 7;299(7):104899. doi: 10.1016/j.jbc.2023.104899. PMID: 37295773

 

Chromophore Structure in an Inactive State of a Novel Photosensor Protein Opn5L1: Resonance Raman Evidence for the Formation of a Deprotonated Adduct at the 11th Carbon Atom

Mizuno M, Sato K, Yamashita T, Sakai K, Imamoto Y, Yamano Y, Wada A, Ohuchi H, Shichida Y, Mizutani Y
J Phys Chem B. 2023 Mar 16;127(10):2169-2176. doi: 10.1021/acs.jpcb.2c08780. Epub 2023 Mar 1. PMID: 36857774

 

Role of Monomer/Tetramer Equilibrium of Rod Visual Arrestin in the Interaction with Phosphorylated Rhodopsin

Imamoto Y, Kojima K, Maeda R, Shichida Y, Oka T
Int. J. Mol. Sci. 2023 Mar 4;24(5):4963. doi: 10.3390/ijms24054963. PMID: 36902393

 

The medaka mutant deficient in eyes shut homolog exhibits opsin transport defects and enhanced autophagy in retinal photoreceptors

Sato K, Liu Y, Yamashita T, Ohuchi H.
Cell Tissue Res. 2023 Feb;391(2):249-267. doi: 10.1007/s00441-022-03702-0. Epub 2022 Nov 22. PMID: 36418571.

 

Reviews and Other Publications

 

Yamashita T, Tsunoda SP. (2023) Welcome to the borderless rhodopsin world. Biophys. Physicobiol. 20, e200044.

山下高廣、和田昭盛 (2023) 「新規な光異性化経路を有する微生物型ロドプシンの発見」 ビタミン 97, 374-7.

 

2022

Convergent evolutionary counterion displacement of bilaterian opsins in ciliary cells

Sakai K, Ikeuchi H, Fujiyabu C, Imamoto Y, Yamashita T.
Cell Mol Life Sci. 2022 Aug 24;79(9):493. doi: 10.1007/s00018-022-04525-6. PMID: 36001156.
プレスリリース

 

Creation of photocyclic vertebrate rhodopsin by single amino acid substitution

Sakai K, Shichida Y, Imamoto Y, Yamashita T.
Elife. 2022 Feb 24;11:e75979. doi: 10.7554/eLife.75979. PMID: 35199641
プレスリリース

研究紹介記事(英語)

研究紹介記事(中国語)

Amino acid residue at position 188 determines the UV-sensitive bistable property of vertebrate non-visual opsin Opn5

Fujiyabu C, Sato K, Nishio Y, Imamoto Y, Ohuchi H, Shichida Y, Yamashita T.
Commun Biol.2022 Jan 18;5(1):63. doi: 10.1038/s42003-022-03010-x. PMID: 35042952

 

Reviews and Other Publications

酒井佳寿美、山下高廣 (2022) 「サイクリックAMP濃度を光で一過的に操作する分子ツールの開発」 医学のあゆみ 283, 1080-1.

小島慧一、柳川正隆、山下高廣（2022） 「カエルとヤモリが夜でも色が分かるワケ」 　比較生理生化学 39, 122-31.

酒井佳寿美、山下高廣 (2022) 「１アミノ酸変異によって光サイクル型視覚ロドプシンを創製する」 　生物物理 62, 351-3.

山下高廣（2022） 「夜の世界をカラフルに見るニホンヤモリ」 　someone（リバネス出版）59, 29.

 

 

2021

Evolutionary adaptation of visual pigments in geckos for their photic environment

Kojima K, Matsutani Y, Yanagawa M, Imamoto Y, Yamano Y, Wada A, Shichida Y, Yamashita T.
Sci Adv.21 Oct;7(40):eabj1316. doi: 10.1126/sciadv.abj1316. Epub 2021 Oct 1. PMID: 34597144
プレスリリース

研究紹介記事

研究紹介記事(中国語)

研究紹介記事(英語)

研究紹介テレビ番組

 

Reviews and Other Publications

山下高廣（2021） 「Ｇ蛋白質共役受容体と紫外光受容蛋白質：紫外線をヒトは感じるか？」脳神経内科 94, 476-481.