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2014

メラノプシンが血管の光弛緩反応を制御する

Melanopsin mediates light-dependent relaxation in blood vessels

Sikka G, Hussmann GP, Pandey D, Cao S, Hori D, Park JT, Steppan J, Kim JH, Barodka V, Myers AC, Santhanam L, Nyhan D, Halushka MK, Koehler RC, Snyder SH, Shimoda LA, Berkowitz DE
PNAS 2014 Dec 16;111(50):17977-82

単粒子解析によるRyanodine Receptorの結晶構造解析

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

Yan Z, Bai XC, Yan C, Wu J, Li Z, Xie T, Peng W, Yin CC, Li X, Scheres SH, Shi Y, Yan N
Nature 2015 Jan 1;517(7532):50-5

ヒトの目の赤外光知覚

Human infrared vision is triggered by two-photon chromophore isomerization

Palczewska G, Vinberg F, Stremplewski P, Bircher MP, Salom D, Komar K, Zhang J, Cascella M, Wojtkowski M, Kefalov VJ, Palczewski K.
PNAS 2014 Dec 16;111(50):E5445-54

GPCRとアレスチンの結合について

Visualization of arrestin recruitment by a G-protein-coupled receptor

Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, Chen X, Hanna R, Choi M, Yao XJ, Klink BU, Kahsai AW, Sidhu SS, Koide S, Penczek PA, Kossiakoff AA, Woods VL Jr, Kobilka BK, Skiniotis G, Lefkowitz RJ
Nature 2014 Aug 14;512(7513):218-22

錐体視物質を用いてGi/oシグナルを制御する

Vertebrate cone opsins enable sustained and highly sensitive rapid control of Gi/o signaling in anxiety circuitry

Masseck OA, Spoida K, Dalkara D, Maejima T, Rubelowski JM, Wallhorn L, Deneris ES, Herlitze S
Neuron 2014 Mar 19;81(6):1263-73

「暗黒ホルモン」としてのメラトニンの進化:ゴカイの繊毛運動におけるメラトニンシグナル

Melatonin signaling controls circadian swimming behavior in marine zooplankton

Tosches MA, Bucher D, Vopalensky P, Arendt D
Cell 2014 Sep 25;159(1):46-57

Müller cellの光誘導能と視覚への影響

Müller cells separate between wavelengths to improve day vision with minimal effect upon night vision

Labin AM, Safuri SK, Ribak EN, Perlman I
Nat Commun 2014 Jul 8;5:4319

シャコのUVフィルター分子

Biological sunscreens tune polychromatic ultraviolet vision in mantis shrimp

Bok MJ, Porter ML, Place AR, Cronin TW
Curr Biol 2014 Jul 21;24(14):1636-42

網膜の発生におけるOnecut1/2の役割

Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development

Sapkota D, Chintala H, Wu F, Fliesler SJ, Hu Z, Mu X
PNAS 2014 Sep 30;111(39):E4086-95

GPCRのエンドサイトーシス・分解経路におけるGタンパク質の役割

Gαs regulates the post-endocytic sorting of G protein-coupled receptors

Rosciglione S, Thériault C, Boily MO, Paquette M, Lavoie C.
Nat Commun 2014 Aug 4;5:4556

メラノプシン／ipRGCが視覚（コントラスト知覚）に関与する

A role for melanopsin in alpha retinal ganglion cells and contrast detection

Schmidt TM, Alam NM, Chen S, Kofuji P, Li W, Prusky GT, Hattar S.
Neuron 2014 May 21;82(4):781-8

哺乳類網膜の概日リズムの制御メカニズム

Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin

Buhr ED, Van Gelder RN
PNAS 2014 Jun 10;111(23):8625-30

ロドプシンとアレスチンの相互作用

Rhodopsin TM6 Can Interact with Two Separate and Distinct Sites on Arrestin: Evidence for Structural Plasticity and Multiple Docking Modes in Arrestin

Sinha A, Jones Brunette AM, Fay JF, Schafer CT, Farrens DL
Biochemistry 2014 May 27;53(20):3294-307

Kisspeptin/Dynorphin/Neurokinin Bの内分泌系

Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat

Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, Navarro VM, Clifton DK, Mori Y, Tsukamura H, Maeda K, Steiner RA, Okamura H
J Neurosci 2010 Feb 24;30(8):3124-32

Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse

Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA
J Neurosci 2009 Sep 23;29(38):11859-66

ツマグロヨコバイの近赤外光感受性

Physiological basis of phototaxis to near-infrared light in Nephotettix cincticeps

Wakakuwa M, Stewart F, Matsumoto Y, Matsunaga S, Arikawa K
J Comp Physiol A 2014 Jun;200(6):527-36

ゼブラフィッシュ水平細胞(H3)と青・UV錐体視細胞のsynaptogenesisとselectivity

Transmission from the dominant input shapes the stereotypic ratio of photoreceptor inputs onto horizontal cells

Yoshimatsu T, Williams PR, D'Orazi FD, Suzuki SC, Fadool JM, Allison WT, Raymond PA, Wong RO
Nat Commun 2014 May 15;5:3699

真菌の遊走子の走光性にロドプシンとグアニル酸シクラーゼの融合タンパクが関与している

A Rhodopsin-Guanylyl Cyclase Gene Fusion Functions in Visual Perception in a Fungus

Avelar GM, Schumacher RI, Zaini PA, Leonard G, Richards TA, Gomes SL
Curr Biol 2014 Jun 2;24(11):1234-1240

QM/MMおよびMCQCを用いたメラノプシンの異性化反応(Conical Intersection dynamics)の解析

Comparison of the isomerization mechanisms of human melanopsin and invertebrate and vertebrate rhodopsins

Rinaldi S, Melaccio F, Gozem S, Fanelli F, Olivucci M
PNAS 2014 Feb 4;111(5):1714-9

µオピオイド受容体のリガンド依存的な順次的・階層的リン酸化

Differentiation of opioid drug effects by hierarchical multi-site phosphorylation

Just S, Illing S, Trester-Zedlitz M, Lau EK, Kotowski SJ, Miess E, Mann A, Doll C, Trinidad JC, Burlingame AL, von Zastrow M, Schulz S.
Mol Pharmacol 2013 Mar;83(3):633-9

チャネルロドプシンをクロライドチャネルに改変する

Conversion of channelrhodopsin into a light-gated chloride channel

Wietek J, Wiegert JS, Adeishvili N, Schneider F, Watanabe H, Tsunoda SP, Vogt A, Elstner M, Oertner TG, Hegemann P
Science 2014 Apr 25;344(6182):409-12

Structure-guided transformation of channelrhodopsin into a light-activated chloride channel

Berndt A, Lee SY, Ramakrishnan C, Deisseroth K.
Science 2014 Apr 25;344(6182):420-4

Functional characterization of flavobacteria rhodopsins reveals a unique class of light-driven chloride pump in bacteria

Yoshizawa S, Kumagai Y, Kim H, Ogura Y, Hayashi T, Iwasaki W, Delong EF, Kogure K.
PNAS 2014 May 6;111(18):6732-7

視細胞特異的な ABCトランスポーター(ABCA4) に関する知見

ATP-binding cassette transporter ABCA4 and chemical isomerization protect photoreceptor cells from the toxic accumulation of excess 11-cis-retinal

Quazi F, Molday RS
Proc Natl Acad Sci U S A 2014 Apr 1;111(13):5024-9

ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer

Quazi F, Lenevich S, Molday RS
Nat Commun　2012 Jun 26;3:925

ES細胞を用いて運動神経を作成・移植をし、光により筋肉の活動を制御

Optical control of muscle function by transplantation of stem cell-derived motor neurons in mice

Bryson JB, Machado CB, Crossley M, Stevenson D, Bros-Facer V, Burrone J, Greensmith L, Lieberam I
Science 2014 Apr 4;344(6179):94-7

オピオイド受容体の結晶構造

Molecular control of δ-opioid receptor signalling

Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC
Nature 2014 Feb 13;506(7487):191-6. Epub 2014 Jan 12.

嗅覚受容細胞における受容体活性の生理的意義

Silencing of odorant receptor genes by G protein βγ signaling ensures the expression of one odorant receptor per olfactory sensory neuron

Ferreira T, Wilson SR, Choi YG, Risso D, Dudoit S, Speed TP, Ngai J
Neuron 2014 Feb 19;81(4):847-59.

Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons

Nakashima A, Takeuchi H, Imai T, Saito H, Kiyonari H, Abe T, Chen M, Weinstein LS, Yu CR, Storm DR, Nishizumi H, Sakano H.
Cell 2013 Sep 12;154(6):1314-25.

ロドプシン(Archaerhodopsin 3)の蛍光を用いて膜電位を測定する

Temporal dynamics of microbial rhodopsin fluorescence reports absolute membrane voltage

Hou JH, Venkatachalam V, Cohen AE
Biophys J 2014 Feb 4;106(3):639-48

最適化したnanobodyを用いて結晶化したβ2アドレナリン受容体のアドレナリン結合型の活性構造

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK
Nature 2013 Oct 24;502(7472):575-9. Epub 2013 Sep 22.

EBI2はコレステロールをリガンドとして認識し、脾臓においてB細胞の移動に関与する

Oxysterols direct B-cell migration through EBI2

Liu C, Yang XV, Wu J, Kuei C, Mani NS, Zhang L, Yu J, Sutton SW, Qin N, Banie H, Karlsson L, Sun S, Lovenberg TW.
Nature 2011 Jul 27;475(7357):519-23

CRF1Rとそのペプチドリガンド(Urocortin-I)の結合について

Genetically Encoded Chemical Probes in Cells Reveal the Binding Path of Urocortin-I to CRF Class B GPCR

Coin I, Katritch V, Sun T, Xiang Z, Siu FY, Beyermann M, Stevens RC, Wang L.
Cell 2013 Dec 5;155(6):1258-69

ヒトデの視覚誘導行動について

Visual navigation in starfish: first evidence for the use of vision and eyes in starfish

Garm A, Nilsson DE
Proc Biol Sci. 2014 Jan 8;281(1777)

ロドプシンのmiss traffickingを制御する新たなC末端シグナル

Signals Governing the Trafficking and Mistrafficking of a Ciliary GPCR, Rhodopsin

Lodowski, K. H. et al.
J Neurosci 33, 13621–13638 (2013)