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2016

　　　

初期アルツハイマー病の記憶状態を光遺伝学的手法(チャネルロドプシン２）を用いて操作する

Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease.

Roy DS, Arons A, Mitchell TI, Pignatelli M, Ryan TJ, Tonegawa S
Nature 2016 MMar 24;531(7595):508-12.

クロライドイオンを透過して興奮を抑える新規チャネルロドプシン

Photochemical reaction cycle transitions during anion channelrhodopsin gating.

Sineshchekov OA, Li H, Govorunova EG, Spudich JL
Proc Natl Acad Sci U S A. 2016 Mar 21. pii: 201525269. [Epub ahead of print]

Gating mechanisms of a natural anion channelrhodopsin.

Sineshchekov OA, Govorunova EG, Li H, Spudich JL
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14236-41.

NEUROSCIENCE. Natural light-gated anion channels: A family of microbial rhodopsins for advanced optogenetics.

Govorunova EG, Sineshchekov OA, Janz R, Liu X, Spudich JL
Science. 2015 Aug 7;349(6248):647-50.

rodとconeの拮抗に基づく新しい色覚神経回路

A neuronal circuit for colour vision based on rod-cone opponency.

Joesch M, Meister M
Nature. 2016 Apr 14;532(7598):236-9.

昆虫のオプシンの多様性について

Conservation, Duplication, and Divergence of Five Opsin Genes in Insect Evolution

Feuda R, Marlétaz F, Bentley MA, Holland PW
Genome Biol Evol. 2016 Feb 9;8(3):579-87.

Extraordinary diversity of visual opsin genes in dragonflies

Futahashi R, Kawahara-Miki R, Kinoshita M, Yoshitake K, Yajima S, Arikawa K, Fukatsu T
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1247-56.

アレスチンの構造変化と下流シグナルの活性化の関係性

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle.

Nuber S, Zabel U, Lorenz K, Nuber A, Milligan G, Tobin AB, Lohse MJ, Hoffmann C
Nature. 2016 Mar 31;531(7596):661-4.

β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation

Eichel K, Jullié D, von Zastrow M
Nat Cell Biol. 2016 Mar;18(3):303-10.

ゼブラフィッシュ幼生の視蓋ニューロンにおける視覚刺激、聴覚刺激、水流刺激への応答

Functional Profiles of Visual-, Auditory-, and Water Flow-Responsive Neurons in the Zebrafish Tectum

Thompson AW, Vanwalleghem GC, Heap LA, Scott EK
Curr Biol. 2016 Mar 21;26(6):743-54.

クリプトクロムによる磁気受容がコンパスの役割を果たす

Cryptochrome 2 mediates directional magnetoreception in cockroaches

Bazalova O, Kvicalova M, Valkova T, Slaby P, Bartos P, Netusil R, Tomanova K, Braeunig P, Lee HJ, Sauman I, Damulewicz M, Provaznik J, Pokorny R, Dolezel D, Vacha M
Proc Natl Acad Sci U S A.2016 Feb 9;113(6):1660-5.

Lampreyの視細胞に関する研究

Single-photon sensitivity of lamprey rods with cone-like outer segments

Morshedian A, Fain GL
Curr Biol.2015 Feb 16;25(4):484-7.

A Cambrian origin for vertebrate rods

Asteriti S, Grillner S, Cangiano L
Elife.2015 Jun 22;4.

Evolution of Vertebrate Phototransduction: Cascade Activation

Lamb TD, Patel H, Chuah A, Natoli RC, Davies WI, Hart NS, Collin SP, Hunt DM
Mol Biol Evol.2016 Aug;33(8):2064-87.

NMRを用いたA2Aアデノシン受容体の様々なリガンドに対応する構造の解析

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

Ye L, Van Eps N, Zimmer M, Ernst OP, Prosser RS
Nature.2016 May 12;533(7602):265-8.

真正細菌のイオンポンプ形ロドプシン非対称機能変換

Asymmetric Functional Conversion of Eubacterial Light-driven Ion Pumps

Inoue K, Nomura Y, Kandori H
J Biol Chem.2016 May 6;291(19):9883-93.

光逃避行動に寄与していると考えられている脳内のOPN5についての電気生理学的解析

Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles

Currie SP, Doherty GH, Sillar KT
Proc Natl Acad Sci U S A.2016 May 24;113(21):6053-8.

アザラシやオットセイのrodを用いた明条件下での色識別能

Rod-cone based color vision in seals under photopic conditions.

Oppermann D, Schramme J, Neumeyer C.
Vision Res. 2016 Jun 3;125:30-40. doi: 10.1016/j.visres.2016.04.009.

哺乳類は夜行性への適応のためにS-coneから派生したrodを獲得した

Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals.

Kim JW, Yang HJ, Oel AP, Brooks MJ, Jia L, Plachetzki DC, Li W, Allison WT, Swaroop A.
Dev Cell. 2016 Jun 20;37(6):520-32.

マウスの嗅覚系のサブシステムにおけるGPCR以外のにおい受容体

A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction.

Greer PL, Bear DM, Lassance JM, Bloom ML, Tsukahara T, Pashkovski SL, Masuda FK, Nowlan AC, Kirchner R, Hoekstra HE, Datta SR.
Cell.2016 Jun 16;165(7):1734-48. doi: 10.1016/j.cell.2016.05.001.

メラノプシンと脳機能との関わりについて

Chemogenetic Activation of Melanopsin Retinal Ganglion Cells Induces Signatures of Arousal and/or Anxiety in Mice.

Milosavljevic N Cehajic-Kapetanovic J Procyk C Lucas R
Current Biology.doi:10.1016/j.cub.2016.06.057

Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light.

Pilorz V Tam S Hughes S Pothecary C Jagannath A Hankins M Bannerman D Lightman S Vyazovskiy V Nolan P Foster R Peirson S Bourgin P
Plos Biology.doi:10.1371/journal.pbio.1002482

エンドソームにおいてβアレスチンとGPCRの複合体がGタンパク質の活性化を行っている

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.

Thomsen AR, Plouffe B, Cahill TJ 3rd, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ.
Cell.2016 Aug 11;166(4):907-19. doi: 10.1016/j.cell.2016.07.004.

ロドプシンの活性化に関する研究

Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation.

Kimata N, Pope A, Eilers M, Opefi CA, Ziliox M, Hirshfeld A, Zaitseva E, Vogel R, Sheves M, Reeves PJ, Smith SO.
Nature Communications.2016 Sep 2;7:12683. doi: 10.1038/ncomms12683.

Free backbone carbonyls mediate rhodopsin activation.

Kimata N, Pope A, Sanchez-Reyes OB, Eilers M, Opefi CA, Ziliox M, Reeves PJ, Smith SO.
Nat Struct Mol Biol.2016 Aug;23(8):738-43. doi: 10.1038/nsmb.3257.

夜盲症を起こすロドプシンT94Iの分子特性について

Structural role of the T94I rhodopsin mutation in congenital stationary night blindness.

Ankita Singhal1, Ying Guo2, Milos Matkovic1, Gebhard Schertler1,3, Xavier Deupi1,4, Elsa CY Yan2 & Joerg Standfuss
EMBO Rep.2016 Oct;17(10):1431-1440. Epub 2016 Jul 25.

チョウの個眼の発現パターンはspineless因子によって決まる

Molecular logic behind the three-way stochastic choices that expand butterfly colour vision.

Michael Perry, Michiyo Kinoshita, Giuseppe Saldi, Lucy Huo,Kentaro Arikawa& Claude Desplan
Nature.535, 280–284 (14 July 2016) doi:10.1038/nature18616

網膜色素変性がオプシンの二量体化不全により生じる

Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.

Birgit Ploier, Lydia N. Caro,w, Takefumi Morizumi, Kalpana Pandey, Jillian N. Pearring, Michael A. Goren, Silvia C. Finnemann, Johannes Graumann, Vadim Y. Arshavsky, Jeremy S. Dittman, Oliver P. Ernst & Anant K. Menon
Nature Communications.7, 12832DOI: 10.1038/ncomms12832

ABCA4とRDH8を欠損したマウスにおける網膜変性の初期分子機構について

Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in 𝐴𝑏𝑐𝑎4−/-𝑅𝑑ℎ8−/− Mice After Light Exposure.

Tanu Parmar, Vipul M. Parmar, Eisuke Arai, Bhubanananda Sahu, Lindsay Perusek,and Akiko Maeda
Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3257-67. doi: 10.1167/iovs.15-18993.

猛禽類の光環境適応メカニズムについて

Retinal transcriptome sequencing sheds light on the adaptation to nocturnal and diurnal lifestyles in raptors.

Wu Y, Hadly EA, Teng W, Hao Y, Liang W, Liu Y, Wang H.
Sci Rep.2016 Sep 20;6:33578. doi: 10.1038/srep33578.

線虫のUV光受容メカニズム

The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor.

Gong J, Yuan Y, Ward A, Kang L, Zhang B, Wu Z, Peng J, Feng Z, Liu J, Xu XZ.
Cell.2016 Nov 17;167(5):1252-1263.

瞳孔対光反射(PLR)を駆動するipRGCの応答様式について

A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction.

Keenan WT, Rupp AC, Ross RA, Somasundaram P, Hiriyanna S, Wu Z, Badea TC, Robinson PR, Lowell BB, Hattar SS.
ELife.2016 Sep 26;5. pii: e15392. doi: 10.7554/eLife.15392.

ウシロドプシンのレチナール解離後の活性について

Decay of an active GPCR: Conformational dynamics　govern agonist rebinding and persistence of an　active, yet empty, receptor state.

Christopher T. Schafera, Jonathan F. Faya, Jay M. Janza, and David L. Farrensa
Proc Natl Acad Sci U S A.October 18, 2016, vol.113 ,no. 42,11961–11966