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2017

　　

6員環レチナールを用いてphotocycleとGTP活性機能のあるロドプシンをつくりだす

Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.

Gulati S, Jastrzebska B, Banerjee S, Placeres AL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K.
Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2608-E2615. doi: 10.1073/pnas.1617446114.

視覚の知覚学習における過剰学習と神経伝達物質濃度との関係

Overlearning hyperstabilizes a skill by rapidly making neurochemical processing inhibitory-dominant.

Shibata K, Sasaki Y, Bang JW, Walsh EG, Machizawa MG, Tamaki M, Chang LH, Watanabe T.
Nat Neurosci. 2017 Mar;20(3):470-475. doi: 10.1038/nn.4490.

ショウジョウバエのクリプトクロムの様々なUV光強度にたいする応答

CRYPTOCHROME mediates behavioral executive choice in response to UV light.

Lisa S. Baika, Keri J. Foglea, Logan Robertsa, Alexis M. Galschiodta, Joshua A. Cheveza, Yocelyn Recinosa, Vinh Nguya, and Todd C. Holmesa,
Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):776-781. doi: 10.1073/pnas.1607989114.

アーキアロドプシンの変異体とレチナールアナログによって長波長蛍光タンパク質をつくりだす

Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore.

Lukas Herwig, Austin J. Rice, Claire N. Bedbrook, Ruijie K. Zhang, Antti Lignell, Jackson K.B. Cahn, Hans Renata, Sheel C. Dodani, Inha Cho, Long Cai, Viviana Gradinaru
Cell Chem Biol. 2017 Mar 16;24(3):415-425. doi: 10.1016/j.chembiol.2017.02.008.

クラスBに属するGPCRの構造について

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.

Liang YL1, Khoshouei M2, Radjainia M3, Zhang Y4, Glukhova A1, Tarrasch J4, Thal DM1, Furness SGB1, Christopoulos G1, Coudrat T1, Danev R2, Baumeister W2, Miller LJ5, Christopoulos A1, Kobilka BK6, Wootten D1, Skiniotis G4, Sexton PM1.
Nature.2017 Apr 24. doi: 10.1038/nature22327.

メラノプシンのリン酸化とその生理的意義

Melanopsin-Encoded Response Properties of Intrinsically Photosensitive Retinal Ganglion Cells.

Mure LS, Hatori M, Zhu Q, Demas J, Kim IM, Nayak SK, Panda S.
Neuron. (2016) 90, 1016-27

C-terminal phosphorylation regulates the kinetics of a subset of melanopsin-mediated behaviors in mice.

Somasundaram P, Wyrick GR, Fernandez DC, Ghahari A, Pinhal CM, Simmonds Richardson M, Rupp AC, Cui L, Wu Z, Brown RL, Badea TC, Hattar S, Robinson PR.
Proc Natl Acad Sci U S A.(2017) 114, 2741-2746

ハエRh7の機能に関する研究

A rhodopsin in the brain functions in circadian photoentrainment in Drosophila.

Ni JD, Baik LS, Holmes TC, Montell C.
Nature. 2017 May 18;545(7654):340-344. doi: 10.1038/nature22325.

Drosophila Rhodopsin 7 can partially replace the structural role of Rhodopsin 1, but not its physiological function.

Grebler R, Kistenpfennig C, Rieger D, Bentrop J, Schneuwly S, Senthilan PR, Helfrich-Forster C.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017 May 12. doi: 10.1007/s00359-017-1182-8.

膜脂質を介した新たな視物質再生経路

Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate.

Kaylor JJ, Xu T, Ingram NT, Tsan A, Hakobyan H, Fain GL, Travis GH.
Nature Commun.2017 May 4;8(1):16. doi: 10.1038/s41467-017-00018-4.

blind ratのRGCに二種類のChannelrhodopsinを共発見して、全波長の光に対して視覚反応を回復させる

Visual Responses of Photoreceptor-Degenerated Rats Expressing Two Different Types of Channelrhodopsin Genes.

Masatoshi Sato, Eriko Sugano, Kitako Tabata, Kei Sannohe, Yoshito Watanabe, Taku Ozaki, Makoto Tamai & Hiroshi Tomita
Sci Rep.2017 Jan 23;7:41210.

緑色盲と網膜色素変性症の原因となるアミノ酸残基が及ぼす影響について

Structural and functional alterations associated with deutan N94K and R330Q mutations of green cone opsin.

Srinivasan S1, Fernandez-Sampedro MA1, Ramon E1, Garriga P2.
Biochim Biophys Acta. 2017 Jul;1863(7):1840-1847. doi: 10.1016/j.bbadis.2017.05.006.

ロドプシン内外の水分子の移動経路についてのコンピュータシミュレーション

Water permeation through the internal water pathway in activated GPCR rhodopsin.

Katsufumi Tomobe, Eiji Yamamoto, Kholmirzo Kholmurodov, Kenji Yasuoka
PLoS One. 2017 May 11;12(5):e0176876. doi: 10.1371/journal.pone.0176876.

アドレナリン受容体のリガンド依存的構造

Single-molecule analysis of ligand efficacy in β2AR-G-protein activation.

Gregorio GG1, Masureel M2, Hilger D2, Terry DS1, Juette M1, Zhao H1, Zhou Z1, Perez-Aguilar JM1, Hauge M3,4,5,6, Mathiasen S3,4, Javitch JA3,4,7, Weinstein H1,8, Kobilka BK2, Blanchard SC1.
Nature.2017 Jun 7. doi: 10.1038/nature22354.

受容体によるＧタンパク質サブタイプの認識メカニズム

Selectivity determinants of GPCR-G-protein binding.

Flock T, Hauser AS, Lund N, Gloriam DE, Balaji S, Babu MM.
Nature.2017 May 18;545(7654):317-322. doi: 10.1038/nature22070.

クリプトクロムの光非依存的な活性の分子的基礎についての研究

FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice.

Hirano A, Braas D, Fu YH, Pta‘k LJ.
r Cell Rep. 2017 Apr 11;19(2):255-266. doi: 10.1016/j.celrep.2017.03.041.

Vertebrate Cryptochromes are Vestigial Flavoproteins.

Kutta RJ, Archipowa N, Johannissen LO, Jones AR, Scrutton NS.
Sci Rep.2017 Mar 20;7:44906. doi: 10.1038/srep44906.