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2019

Heliorhodpsinの結晶構造

Crystal structure of heliorhodopsin.

Shihoya W, Inoue K, Singh M, Konno M, Hososhima S, Yamashita K, Ikeda K, Higuchi A, Izume T, Okazaki S, Hashimoto M, Mizutori R, Tomida S, Yamauchi Y, Abe-Yoshizumi R, Katayama K, Tsunoda SP, Shibata M, Furutani Y, Pushkarev A, Béjà O, Uchihashi T, Kandori H, Nureki O.
Nature 2019 Oct;574(7776):132-136. doi: 10.1038/s41586-019-1604-6.

円盤膜中でのロドプシンの動態

Raftophilic rhodopsin-clusters offer stochastic platforms for G protein signalling in retinal discs.

Hayashi F, Saito N, Tanimoto Y, Okada K, Morigaki K, Seno K, Maekawa S.
Commun biol.2019 Jun 14;2:209. doi: 10.1038/s42003-019-0459-6.

無脊椎動物の偏光視覚情報形成

Parallel processing of polarization and intensity information in fiddler crab vision.

Smithers SP, Roberts NW, How MJ.
Sci adv.2019 Aug 21;5(8):eaax3572. doi: 10.1126/sciadv.aax3572.

Horsefly object-directed polarotaxis is mediated by a stochastically distributed ommatidial subtype in the ventral retina.

Meglič A, Ilić M, Pirih P, Škorjanc A, Wehling MF, Kreft M, Belušič G.
Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21843-21853. doi: 10.1073/pnas.1910807116. .

光遺伝学的な視機能回復技術

Restoration of visual function by transplantation of optogenetically engineered photoreceptors.

Garita-Hernandez M, Lampič M, Chaffiol A, Guibbal L, Routet F, Santos-Ferreira T, Gasparini S, Borsch O, Gagliardi G, Reichman S, Picaud S, Sahel JA, Goureau O, Ader M, Dalkara D, Duebel J.
Nat Commun.2019 Oct 4;10(1):4524. doi: 10.1038/s41467-019-12330-2.

襟鞭毛虫の光依存的な多細胞動態

Light-regulated collective contractility in a multicellular choanoflagellate.

Brunet T, Larson BT, Linden TA, Vermeij MJA, McDonald K, King N.
Science2019 Oct 18;366(6463):326-334. doi: 10.1126/science.aay2346.

哺乳類の酸味受容メカニズム

Sour Sensing from the Tongue to the Brain.

Zhang J, Jin H, Zhang W, Ding C, O'Keeffe S, Ye M, Zuker CS.
Cell 2019 Oct 3;179(2):392-402.e15. doi: 10.1016/j.cell.2019.08.031.

An evolutionarily conserved gene family encodes proton-selective ion channels.

Tu YH, Cooper AJ, Teng B, Chang RB, Artiga DJ, Turner HN, Mulhall EM, Ye W,Smith AD, Liman ER.
Science 2018 Mar 2;359(6379):1047-1050. doi: 10.1126/science.aao3264.

ハトCry4の結晶構造

Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon.

Zoltowski BD, Chelliah Y, Wickramaratne A, Jarocha L, Karki N, Xu W, Mouritsen H, Hore PJ, Hibbs RE, Green CB, Takahashi JS.
Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19449-19457. doi: 10.1073/pnas.1907875116.

ヒトメラノサイトにおけるOpn3の生理機能

Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor.

Ozdeslik RN, Olinski LE, Trieu MM, Oprian DD, Oancea E.
Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11508-11517. doi: 10.1073/pnas.1902825116.

ロドプシン二量体化阻害剤のスクリーニング

Stereospecific modulation of dimeric rhodopsin.

Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K
FASEB J.　2019 May 23:fj201900443RR. doi: 10.1096/fj.201900443RR.

近赤外光感受性マウスの作製

Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae.

Ma Y, Bao J, Zhang Y, Li Z, Zhou X, Wan C, Huang L, Zhao Y, Han G, Xue T.
Cell　2019 Apr 4;177(2):243-255.e15. doi: 10.1016/j.cell.2019.01.038.

GPCR C末のリン酸化パターンとアレスチン機能発現の関係

Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation.

Mayer D, Damberger FF, Samarasimhareddy M, Feldmueller M, Vuckovic Z, Flock T, Bauer B, Mutt E, Zosel F, Allain FHT, Standfuss J, Schertler GFX, Deupi X, Sommer ME, Hurevich M, Friedler A, Veprintsev DB.
Nat Commun.　2019 Mar 1;10(1):1261. doi: 10.1038/s41467-019-09204-y.

Channelrhodopsin-2の光反応サイクルモデル

Unifying photocycle model for light adaptation and temporal evolution of cation conductance in channelrhodopsin-2.

Kuhne J, Vierock J, Tennigkeit SA, Dreier MA, Wietek J, Petersen D, Gavriljuk K, El-Mashtoly SF, Hegemann P, Gerwert K.
Proc Natl Acad Sci U S A.　2019 May 7;116(19):9380-9389. doi: 10.1073/pnas.1818707116. Epub 2019 Apr 19.

光依存的な錐体視物質再生におけるミュラー細胞のRGRオプシンの役割

Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells.

Morshedian A, Kaylor JJ, Ng SY, Tsan A, Frederiksen R, Xu T, Yuan L, Sampath AP, Radu RA, Fain GL, Travis GH.
Neuron 2019 Apr 22.doi: 10.1016/j.neuron.2019.04.004.

哺乳類Opn5の生理機能解析

An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye.

Nguyen MT, Vemaraju S, Nayak G, Odaka Y, Buhr ED, Alonzo N, Tran U, Batie M, Upton BA, Darvas M, Kozmik Z, Rao S, Hegde RS, Iuvone PM, Van Gelder RN, Lang RA.
Nat Cell Biol. 2019 Apr 21(4):420-429. doi: 10.1038/s41556-019-0301-x.

Impaired Circadian Photoentrainment in Opn5-Null Mice.

Ota W, Nakane Y, Hattar S, Yoshimura T.
iScience 2018 Aug 31;6:299-305. doi: 10.1016/j.isci.2018.08.010.

クモロドプシンの光反応

The Two-Photon Reversible Reaction of the Bistable Jumping Spider Rhodopsin-1.

Ehrenberg D, Varma N, Deupi X, Koyanagi M, Terakita A, Schertler GFX, Heberle J, Lesca E.
Biophys J.　2019 Apr 2;116:1248-1258. doi: 10.1016/j.bpj.2019.02.025.

　　

ショウジョウバエの色識別システムについて

Color Processing in the Early Visual System of Drosophila.

Schnaitmann C, Haikala V, Abraham E, Oberhauser V, Thestrup T, Griesbeck O, Reiff DF.
Cell　2018 Jan 11;172(1-2):318-330.e18. doi: 10.1016/j.cell.2017.12.018.

　　

レチノイン酸結合蛋白質変異体を用いた、吸収波長の長波長化について

Tuning the electronic absorption of protein-embedded all-trans-retinal.

Wang W, Nossoni Z, Berbasova T, Watson CT, Yapici I, Lee KS, Vasileiou C, Geiger JH, Borhan B.
Science　2012 Dec 7;338(6112):1340-3. doi: 10.1126/science.1226135.

　　　　

レチノイン酸結合蛋白質変異体を用いた、レチナール異性化メカニズムの解析について

Mimicking Microbial Rhodopsin Isomerization in a Single Crystal.

Ghanbarpour A, Nairat M, Nosrati M, Santos EM, Vasileiou C, Dantus M, Borhan B, Geiger JH.
J Am Chem Soc　2018 Dec 22. doi: 10.1021/jacs.8b12493.