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2020

イカの色素胞の構造色

Dynamic pigmentary and structural coloration within cephalopod chromatophore organs

Thomas L. Williams, Stephen L. Senft, Jingjie Yeo, Francisco J. Martín-Martínez, Alan M. Kuzirian, Camille A. Martin, Christopher W. DiBona, Chun-Teh Chen, Sean R. Dinneen, Hieu T. Nguyen, Conor M. Gomes, Joshua J. C. Rosenthal, Matthew D. MacManes, Feixia Chu, Markus J. Buehler, Roger T. Hanlon & Leila F. Deravi
Nat Commun.2019 Mar 1;10(1):1004. doi: 10.1038/s41467-019-08891-x.

PYPを結晶化したときの光サイクルの変化

Confinement in crystal lattice alters entire photocycle pathway of the Photoactive Yellow Protein

Konold PE, Arik E, Weißenborn J, Arents JC, Hellingwerf KJ, van Stokkum IHM, Kennis JTM, Groot ML.
Nat Commun.2020 Aug 25;11(1):4248. doi: 10.1038/s41467-020-18065-9.

末梢嗅覚系における受容体レベルでの匂い情報のエンコーディング

Widespread receptor-driven modulation in peripheral olfactory coding

Xu L, Li W, Voleti V, Zou DJ, Hillman EMC, Firestein S.
Science.2020;368(6487)doi:10.1126/science.aaz5390

近赤外光を吸収するロドプシン

NeoR, a near-infrared absorbing rhodopsin.

Broser M, Spreen A, Konold PE, Peter E, Adam S, Borin V, Schapiro I, Seifert R, Kennis JTM, Bernal Sierra YA, Hegemann P.
Nat Commun.2020 Nov 10;11(1):5682. doi: 10.1038/s41467-020-19375-8.

ネッタイシマカが花の蜜と血液を感覚的に区別している

Sensory Discrimination of Blood and Floral Nectar byAedes aegypti Mosquitoes.

Veronica Jove, Zhongyan Gong, Felix J.H. Hol Zhilei Zhao, Trevor R. Sorrells, Thomas S. Carroll, Manu Prakash, Carolyn S. McBride, and Leslie B. Vosshall
Neuron.2020 Oct 8;S0896-6273(20)30719-4. doi: 10.1016/j.neuron.2020.09.019.

夜間のブルーライトが鬱様行動を引き起こすその神経経路

A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice.

Kai An, Huan Zhao, Ying Miao, Qi Xu, Yu-Fei Li, Yu-Qian Ma, Yi-Ming Shi, Jia-Wei Shen, Jian-Jun Meng, Yong-Gang Yao, Zhi Zhang, Ju-Tao Chen, Jin Bao, Mei Zhang, Tian Xue
Nat Neurosci.2020 Jul;23(7):869-880. doi: 10.1038/s41593-020-0640-8.

季節変化及び環境適応のための体温調節メカニズム

Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons.

Zhang KX, D'Souza S, Upton BA, Kernodle S, Vemaraju S, Nayak G, Gaitonde KD, Holt AL, Linne CD, Smith AN, Petts NT, Batie M, Mukherjee R, Tiwari D, Buhr ED, Van Gelder RN, Gross C, Sweeney A, Sanchez-Gurmaches J, Seeley RJ, Lang RA.
Nature.2020 Sep;585(7825):420-425. doi: 10.1038/s41586-020-2683-0. Epub 2020 Sep 2. PMID: 32879486

A discrete neuronal circuit induces a hibernation-like state in rodents.

Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T.
Nature.2020 Jul;583(7814):109-114. doi: 10.1038/s41586-020-2163-6. Epub 2020 Jun 11. PMID: 32528181

ゼブラフィッシュUV coneの網膜内局所的ネットワークの存在

Fovea-like Photoreceptor Specializations Underlie Single UV Cone Driven Prey-Capture Behavior in Zebrafish.

Yoshimatsu T, Schröder C, Nevala NE, Berens P, Baden T.
Neuron. 2020 Jul 22;107(2):320-337.e6. doi: 10.1016/j.neuron.2020.04.021. Epub 2020 May 29.

脊椎動物視細胞におけるカルシウムイメージング

Calcium flares and compartmentalization in rod photoreceptors.

Li Y, Falleroni F, Mortal S, Bocchero U, Cojoc D, Torre V.
Proc Natl Acad Sci USA. 2020 Sep 1;117(35):21701-21710. doi: 10.1073/pnas.2004909117.

Mechanosensitivity is an essential component of phototransduction in vertebrate rods.

Bocchero U, Falleroni F, Mortal S, Li Y, Cojoc D, Lamb T, Torre V.
PLoS Biol.2020 Jul 15;18(7):e3000750. doi: 10.1371/journal.pbio.3000750.

視覚ロドプシンの活性化と水和の関係について

Activation of the G-Protein-Coupled Receptor Rhodopsin by Water.

Chawla U, Perera S, Fried S, Eitel A, Mertz B, Weerasinghe N, Pitman M,Struts A, Brown MF.
Angew Chem Int Ed Engl. 2020 Jun 28. doi: 10.1002/anie.202003342.

Small-Angle Neutron Scattering Reveals Energy Landscape for Rhodopsin Photoactivation.

Perera SMDC, Chawla U, Shrestha UR, Bhowmik D, Struts AV, Qian S, Chu XQ,Brown MF.
J Phys Chem Lett.2018 Dec 20;9(24):7064-7071. doi:10.1021/acs.jpclett.8b03048.

生細胞でのGタンパク質活性化の新しい検出方法

Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design.

Maziarz M, Park JC, Leyme A, Marivin A, Garcia-Lopez A, Patel PP, Garcia-Marcos M.
Cell.Jun 27:S0092-8674(20)30752-2. doi: 10.1016/j.cell.2020.06.020.

GPCRの活性化を制御するマイクロスイッチ領域の探索

Computational Design of G Protein-Coupled Receptor Allosteric Signal Transductions

Chen KM, Keri D, Barth P.
Nat Chem Biol.Jan;16(1):77-86. doi: 10.1038/s41589-019-0407-2.

Na+ポンプの光反応中間体の構造について

Femtosecond-to-millisecond structural changes in a light-driven sodium pump.

kopintsev P, Ehrenberg D, Weinert T, James D, Kar RK, Johnson PJM, Ozerov D, Furrer A, Martiel I, Dworkowski F, Nass K, Knopp G, Cirelli C, Arrell C, Gashi D, Mous S, Wranik M, Gruhl T, Kekilli D, Brunle S, Deupi X, Schertler GFX, Benoit RM, Panneels V, Nogly P, Schapiro I, Milne C, Heberle J, Standfuss J.
Nature.May 20. doi: 10.1038/s41586-020-2307-8.

Molecular mechanism of light-driven sodium pumping.

Kovalev K, Astashkin R, Gushchin I, Orekhov P, Volkov D, Zinovev E, Marin E, Rulev M, Alekseev A, Royant A, Carpentier P, Vaganova S, Zabelskii D, Baeken C, Sergeev I, Balandin T, Bourenkov G, Carpena X, Boer R, Maliar N, Borshchevskiy V, Buldt G, Bamberg E, Gordeliy V.
Nat Commun.2020 May 1;11(1):2137. doi: 10.1038/s41467-020-16032-y.

NTSR1のシグナル伝達経路をβ-Arrestinに偏らせるアロステリックなモジュレーター

β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.

Slosky LM, Bai Y, Toth K, Ray C, Rochelle LK, Badea A, Chandrasekhar R, Pogorelov VM, Abraham DM, Atluri N, Peddibhotla S, Hedrick MP, Hershberger P, Maloney P, Yuan H, Li Z, Wetsel WC, Pinkerton AB, Barak LS, Caron MG.
Cell.2020;181(6):1364-1379.e14. doi:10.1016/j.cell.2020.04.053

青色光で大腸菌の運動性をコントロールする

Blue Light-Directed Cell Migration, Aggregation, and Patterning

Zhang J, Luo Y, Poh CL.
J Mol Biol. 2020 May 1;432(10):3137-3148. doi: 10.1016/j.jmb.2020.03.029.

線維芽細胞を５つの小分子で処理すると、桿体のような細胞になる

Pharmacologic Fibroblast Reprogramming Into Photoreceptors Restores Vision

Mahato B, Kaya KD, Fan Y, Sumien N, Shetty RA, Zhang W, Davis D, Mock T, Batabyal S, Ni A, Mohanty S, Han Z, Farjo R, Forster MJ, Swaroop A, Chavala SH.
Nature. Nature. 2020 May;581(7806):83-88. doi: 10.1038/s41586-020-2201-4.

より低侵襲性の光遺伝学実験を可能にする高光感度オプシンの開発

An Ultra-Sensitive Step-Function Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques

Xin Gong, Diego Mendoza-Halliday, Jonathan T Ting, Tobias Kaiser, Xuyun Sun, André M Bastos, Ralf D Wimmer, Baolin Guo, Qian Chen, Yang Zhou, Maxwell Pruner, Carolyn W-H Wu, Demian Park, Karl Deisseroth, Boaz Barak, Edward S Boyden, Earl K Miller, Michael M Halassa, Zhanyan Fu, Guoqiang Bi, Robert Desimone , Guoping Feng
Neuron. 2020 Apr 29;S0896-6273(20)30239-7. doi: 10.1016/j.neuron.2020.03.032.

動物の定位行動

Mantis Shrimp Navigate Home Using Celestial and Idiothetic Path Integration.

Patel RN, Cronin TW.
Curr Biol. 2020 Apr 4:S0960-9822(20)30361-4. doi: 10.1016/j.cub.2020.03.023.

Multimodal cue integration in the dung beetle compass.

Marie Dacke, Adrian T. A. Bell, James J. Foster, Emily J. Baird, Martin F. Strube-Bloss, Marcus J. Byrne, and Basil el Jundi
Proc Natl Acad Sci USA July 9, 2019 116 (28) 14248-14253

ショウジョウバエのロドプシンと味覚の関係

Functions of Opsins in Drosophila Taste.

Leung NY, Thakur DP, Gurav AS, Kim SH, Di Pizio A, Niv MY, Montell C.
Curr Biol. 2020 Apr 20;30(8):1367-1379.e6. doi: 10.1016/j.cub.2020.01.068.

Temperature and Sweet Taste Integration in Drosophila.

Li Q, DeBeaubien NA, Sokabe T, Montell C.
Curr Biol. 2020 Apr 23:S0960-9822(20)30436-X. doi: 10.1016/j.cub.2020.03.066.

脂肪細胞におけるOpn3を介した光受容の役割

Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing.

Nayak G, Zhang KX, Vemaraju S, Odaka Y, Buhr ED, Holt-Jones A, Kernodle S, Smith AN, Upton BA, D'Souza S, Zhan JJ, Diaz N, Nguyen MT, Mukherjee R, Gordon SA, Wu G, Schmidt R, Mei X, Petts NT, Batie M, Rao S, Hogenesch JB, Nakamura T, Sweeney A, Seeley RJ, Van Gelder RN, Sanchez-Gurmaches J, Lang RA.
Cell Rep. 2020 Jan 21;30(3):672-686.e8. doi: 10.1016/j.celrep.2019.12.043.

Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes.

Sato M, Tsuji T, Yang K, Ren X, Dreyfuss JM, Huang TL, Wang CH, Shamsi F,Leiria LO, Lynes MD, Yau KW, Tseng YH.
PLoS Biol.2020 Feb 10;18(2):e3000630. doi: 10.1371/journal.pbio.3000630.

構造的にプロトンポンプに似たチャネルロドプシンの物性

Conductance Mechanisms of Rapidly Desensitizing Cation Channelrhodopsins from Cryptophyte Algae.

Sineshchekov OA, Govorunova EG, Li H, Wang Y, Melkonian M, Wong GK, Brown LS, Spudich JL.
mBio. 2020 Apr 21;11(2). pii: e00657-20. doi: 10.1128/mBio.00657-20.

GPCRとbetaアレスチンの複合体の構造

Structure of the neurotensin receptor 1 in complex with β-arrestin 1.

Huang W, Masureel M, Qu Q, Janetzko J, Inoue A, Kato HE, Robertson MJ, Nguyen KC, Glenn JS, Skiniotis G, Kobilka BK.
Nature. 2020 Mar;579(7798):303-308. doi: 10.1038/s41586-020-1953-1.

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.

Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G.
Nature. 2020 Mar;579(7798):297-302. doi: 10.1038/s41586-020-1954-0.

ヒト網膜における単一細胞での遺伝子発現プロファイル

Single-nuclei RNA-seq on human retinal tissue provides improved transcriptome profiling.

Liang Q, Dharmat R, Owen L, Shakoor A, Li Y, Kim S, Vitale A, Kim I, Morgan D, Liang S, Wu N, Chen K, DeAngelis MM, Chen R.
Nat Commun. 2019 Dec 17;10(1):5743. doi: 10.1038/s41467-019-12917-9.

MA single-cell transcriptome atlas of the adult human retina.

Lukowski SW, Lo CY, Sharov AA, Nguyen Q, Fang L, Hung SS, Zhu L, Zhang T, Grünert U, Nguyen T, Senabouth A, Jabbari JS, Welby E, Sowden JC, Waugh HS, Mackey A, Pollock G, Lamb TD, Wang PY, Hewitt AW, Gillies MC, Powell JE, Wong RC.
EMBO J. 2020 Jan 6;30(1):42-53.e4. doi: 10.1016/j.cub.2019.11.021.

植物の重力屈性

Polar recruitment of RLD by LAZY1-like protein during gravity signaling in root branch angle control.

Furutani M, Hirano Y, Nishimura T, Nakamura M, Taniguchi M, Suzuki K, Oshida R, Kondo C, Sun S, Kato K, Fukao Y, Hakoshima T, Morita MT.
Nat Commun. 2020 Jan 3;11(1):76. doi: 10.1038/s41467-019-13729-7.

マウスがもつ効率的な光検知のための行動戦略

Mice Reach Higher Visual Sensitivity at Night by Using a More Efficient Behavioral Strategy.

Koskela S, Turunen T, Ala-Laurila P.
Curr Biol. 2020 Jan 6;30(1):42-53.e4. doi: 10.1016/j.cub.2019.11.021.