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2021

オレキシン1受容体にサブタイプ選択的なアンタゴニストの構造ベース創薬

Structure-based development of a subtype-selective orexin 1 receptor antagonist.

Hellmann J, Drabek M, Yin J, Gunera J, Pröll T, Kraus F, Langmead CJ, Hübner H, Weikert D, Kolb P, Rosenbaum DM, Gmeiner P. Proc Natl
Acad Sci U S A. 2020 Jul 28;117(30):18059-18067. doi: 10.1073/pnas.2002704117. Epub 2020 Jul 15.

中間赤外線の照射によって非侵襲的にニューロンを活性化させ、連合学習の成立を早められる

Non-invasive, opsin-free mid-infrared modulation activates cortical neurons and accelerates associative learning.

Jianxiong Zhang, Yong He, Shanshan Liang, Xiang Liao, Tong Li, Zhi Qiao, Chao Chang, Hongbo Jia & Xiaowei Chen
Nat Commun.2021 May 12;12(1):2730. doi: 10.1038/s41467-021-23025-y. PMID: 33980868; PMCID: PMC8115038

渡り鳥の Cryptochrome 4 に磁気感受性がある

Magnetic sensitivity of cryptochrome 4 from a migratory songbird.

Xu J, Jarocha LE, Zollitsch T, Konowalczyk M, Henbest KB, Richert S,Golesworthy MJ, Schmidt J, Déjean V, Sowood DJC, Bassetto M, Luo J, Walton JR, Fleming J, Wei Y, Pitcher TL, Moise G, Herrmann M, Yin H, Wu H, Bartölke R, Käsehagen SJ, Horst S, Dautaj G, Murton PDF, Gehrckens AS, Chelliah Y, Takahashi JS, Koch KW, Weber S, Solov'yov IA, Xie C, Mackenzie SR, Timmel CR, Mouritsen H, Hore PJ.
Nature. 2021 Jun;594(7864):535-540. doi: 10.1038/s41586-021-03618-9. Epub 2021 Jun 23.PMID: 34163056

覚醒時および睡眠時の鳥類の瞳孔について

Pupillary behavior during wakefulness, non-REM sleep, and REM sleep in birds is opposite that of mammals.

Ungurean G, Martinez-Gonzalez D, Massot B, Libourel PA, Rattenborg NC.
Curr Biol.2021 Oct 7:S0960-9822(21)01316-6. doi: 10.1016/j.cub.2021.09.060.

コレステロールによるGPCRの機能調節の分子メカニズム

A molecular sensor for cholesterol in the human serotonin1A receptor.

Kumar GA, Sarkar P, Stepniewski TM, Jafurulla M, Singh SP, Selent J, Chattopadhyay A.
Sci Adv.2021 Jul 23;7(30)doi: 10.1126/sciadv.abh2922.

網膜が早い段階で光情報を「カラー」と「グレースケール」に分解する視覚のメカニズム

Ancestral circuits for vertebrate color vision emerge at the first retinal synapse.

Yoshimatsu T, Bartel P, Schröder C, Janiak FK, St-Pierre F, Berens P, Baden T.
Sci Adv.2021 Oct 15;7(42):eabj6815. doi: 10.1126/sciadv.abj6815. Epub 2021 Oct 13. PMID: 34644120.

目の水晶体（レンズ）が透明になるメカニズム

Organelle degradation in the lens by PLAAT phospholipases.

Morishita H, Eguchi T, Tsukamoto S, Sakamaki Y, Takahashi S, Saito C, Koyama-Honda I, Mizushima N.
Nature.2021 Apr;592(7855):634-638. doi: 10.1038/s41586-021-03439-w. Epub 2021 Apr 14. PMID: 33854238

視床下部の進化的起源

The hypothalamus predates the origin of vertebrates.

Lemaire LA, Cao C, Yoon PH, Long J, Levine M.
Sci. Adv.2021 Apr 28;7(18):eabf7452. doi: 10.1126/sciadv. abf7452. PMID: 33910896; PMCID: PMC8081355.

スチレンマレイン酸共重合体（SMA）で可溶化したロドプシンの性質

Styrene-maleic acid copolymer effects on the function of the GPCR rhodopsin in lipid nanoparticles.

Szundi I, Pitch SG, Chen E, Farrens DL, Kliger DS.
Biophys J.2021 Sep 10:S0006-3495(21)00746-3. doi: 10.1016/j.bpj.2021.09.012. Online ahead of print.PMID: 34509506

Functional integrity of membrane protein rhodopsin solubilized by styrene-maleic acid copolymer.

Pitch SG, Yao W, Szundi I, Fay J, Chen E, Shumate A, Kliger DS, Farrens DL.
Biophys J.2021 Aug 17;120(16):3508-3515. doi: 10.1016/j.bpj.2021.05.008. Epub 2021 May 20.PMID: 34022241

カンナビノイドCB1受容体とドーパミンD4受容体による桿体-錐体間結合の昼夜差調節

Interactions of cone cannabinoid CB1 and dopamine D4 receptors increase day/night difference in rod-cone gap junction coupling in goldfish retina.

Cao J, Mangel SC.
J Physiol.2021 Jul 12. doi: 10.1113/JP281308. Epub ahead of print. PMID: 34252195.

アニオン型チャネルロドプシンを用いたオプトジェネティクスの植物への適用

Optogenetic control of the guard cell membrane potential and stomatal movement by the light-gated anion channel GtACR1.

Huang S, Ding M, Roelfsema MRG, Dreyer I, Scherzer S, Al-Rasheid KAS, Gao S, Nagel G, Hedrich R, Konrad KR.
Sci Adv.2021 Jul 9;7(28):eabg4619 doi: 10.1126/sciadv.abg4619. PMID: 34244145; PMCID: PMC8270491.

「短波長光による近視抑制効果」として、Opn5 KOマウスの機能解析

Violet light suppresses lens-induced myopia via neuropsin (OPN5) in　mice.

Jiang X, Pardue MT, Mori K, Ikeda SI, Torii H, D'Souza S, Lang RA, Kurihara T, Tsubota K.
PNAS.(2021) 118,:e2018840118.doi: 10.1073/pnas.2018840118. PMID: 34031241; PMCID: PMC8179197.

phytochrome類の構造や機能

Differing biophysical properties underpin the unique signaling potentials within the plant phytochrome photoreceptor families.

Burgie ES, Gannam ZTK, McLoughlin KE, Sherman CD, Holehouse AS, Stankey RJ,Vierstra RD.
PNAS.2021 Jun 1;118(22):e2105649118. doi: 10.1073/pnas.2105649118.PMID: 34039713 Free article.

Structural basis of the protochromic green/red photocycle of the chromatic acclimation sensor RcaE.

Nagae T, Unno M, Koizumi T, Miyanoiri Y, Fujisawa T, Masui K, Kamo T, Wada K, Eki T, Ito Y, Hirose Y, Mishima M.
cell.184, 1693–1705 April 1, 2021 PNAS.2021 May 18;118(20):e2024583118. doi: 10.1073/pnas.2024583118.PMID: 33972439

コナジラミというアブラムシの一種である害虫に植物の遺伝子が水平伝播した

Whitefly hijacks a plant detoxification gene that neutralizes plant toxins.

Jixing Xia, Zhaojiang Guo, Zezhong Yang, ..., Wannes Dermauw, Ted C.J. Turlings, Youjun Zhang
cell.184, 1693–1705 April 1, 2021 doi.org/10.1016/j.cell.2021.02.014

センサリーロドプシンⅡの光異性化と電場の関係性についてのシミュレーション

Electrostatic Control of Photoisomerization in Channelrhodopsin 2.

Liang R, Yu JK, Meisner J, Liu F, Martinez TJ.
jacs.2021 Apr 14;143(14):5425-5437. doi: 10.1021/jacs.1c00058. Epub 2021 Apr 1. DOI: 10.1021/jacs.1c00058

一次繊毛で生成されたcAMPが繊毛外のcAMPとは異なる情報を伝達し、細胞が繊毛内外のGPCRシグナルを区別する

Vertebrate cells differentially interpret ciliary and extraciliary cAMP.

Truong ME, Bilekova S, Choksi SP, Li W, Bugaj LJ, Xu K, Reiter JF.
cell.2021 Apr 27:S0092-8674(21)00437-2. doi: 10.1016/j.cell.2021.04.002.

シジミチョウが獲得した赤い色覚

The evolution of red color vision is linked to coordinated rhodopsin tuning in lycaenid butterflies.

Liénard MA, Bernard GD, Allen A, Lassance JM, Song S, Childers RR, Yu N, Ye D, Stephenson A, Valencia-Montoya WA, Salzman S, Whitaker MRL, Calonje M, Zhang F,
pnas.2021 Feb 9;118(6):e2008986118. doi: 10.1073/pnas.2008986118. PMID: 33547236; PMCID: PMC8017955.

Gタンパク質とβアレスチンの複合体を介した、GPCRによる新たなシグナル伝達機構

Noncanonical scaffolding of G αi and β-arrestin by G protein-coupled receptors.

Smith JS, Pack TF, Inoue A, Lee C, Zheng K, Choi I, Eiger DS, Warman A, Xiong X, Ma Z, Viswanathan G, Levitan IM, Rochelle LK, Staus DP, Snyder JC, Kahsai AW, Caron MG, Rajagopal S.
Science.2021 Mar 12;371(6534):eaay1833. doi: 10.1126/science.aay1833. Epub 2021 Jan 21. PMID: 33479120

眼のない線虫の色識別

C. elegans discriminates colors to guide foraging.

Ghosh DD, Lee D, Jin X, Horvitz HR, Nitabach MN.
Science.2021 Mar 5;371(6533):1059-1063. doi: 10.1126/science.abd3010.

ウシオプシンのGtあるいはアレスチンとの結合能を検出する実験系

Novel fluorescent GPCR biosensor detects retinal equilibrium binding to opsin and active G protein and arrestin signaling conformations

Schafer CT, Shumate A, Farrens DL.
J Biol Chem.2020 Dec 18;295(51):17486-17496. doi: 10.1074/jbc.RA120.014631..

Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state.

Schafer CT, Fay JF, Janz JM, Farrens DL.
Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11961-11966. doi: 10.1073/pnas.1606347113.

Conformational selection and equilibrium governs the ability of retinals to bind opsin.

Schafer CT, Farrens DL.
J Biol Chem.2015 Feb 13;290(7):4304-18. doi: 10.1074/jbc.M114.603134.

弱光下における光感受性網膜神経節細胞の役割

A noncanonical inhibitory circuit dampens behavioral sensitivity to light.

Sonoda T, Li JY, Hayes NW, Chan JC, Okabe Y, Belin S, Nawabi H, Schmidt TM
Science.2020 May 1;368(6490):527-531. doi: 10.1126/science.aay3152.