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2022

哺乳類の錘体細胞においてミトコンドリアがマイクロレンズとして機能する

Mitochondria in cone photoreceptors act as microlenses to enhance photon delivery and confer directional sensitivity to light

Ball JM, Chen S, Li W.
Sci Adv. 2022 Mar 4;8(9):eabn2070. doi: 10.1126/sciadv.abn2070. Epub 2022 Mar 2. PMID: 35235359; PMCID: PMC8890704.

機械学習によるタンパク質設計

Robust deep learning–based protein sequence design using ProteinMPNN.

Dauparas J, Anishchenko I, Bennett N, Bai H, Ragotte RJ, Milles LF, Wicky BIM, Courbet A, de Haas RJ, Bethel N, Leung PJY, Huddy TF, Pellock S, Tischer D, Chan F, Koepnick B, Nguyen H, Kang A, Sankaran B, Bera AK, King NP, Baker D.
Science.2022 Oct 7;378(6615):49-56. doi: 10.1126/science.add2187. Epub 2022 Sep 15. PMID: 36108050.

クリプトクロムによる概月リズムの同期メカニズム

A Cryptochrome adopts distinct moon- and sunlight states and functions as sun- versus moonlight interpreter in monthly oscillator entrainment.

Poehn B, Krishnan S, Zurl M, Coric A, Rokvic D, Häfker NS, Jaenicke E, Arboleda E, Orel L, Raible F, Wolf E, Tessmar-Raible K.
Nat Commun.2022 Sep 5;13(1):5220. doi: 10.1038/s41467-022-32562-z. PMID: 36064778; PMCID: PMC9445029.

人に対する蚊の誘因性と人間の皮膚由来のカルボン酸との関連性

Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels.

De Obaldia ME, Morita T, Dedmon LC, Boehmler DJ, Jiang CS, Zeledon EV, Cross JR, Vosshall LB.
Cell.2022 Oct 27;185(22):4099-4116.e13. doi: 10.1016/j.cell.2022.09.034. Epub 2022 Oct 18. PMID: 36261039.

発生段階が終わりすでに完成された網膜の損傷を回復する方法

Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors.

Cao Y, Fajardo D, Guerrero-Given D, Samuel MA, Ohtsuka T, Boye SE, Kamasawa N, Martemyanov KA.
Curr Biol.2022 Sep 23:S0960-9822(22)01460-9. doi: 10.1016/j.cub.2022.09.016. Epub ahead of print. PMID: 36179691.

脳の発達における網膜神経節細胞を介した光情報伝達の役割

Melanopsin retinal ganglion cells mediate light-promoted brain development.

Hu J, Shi Y, Zhang J, Huang X, Wang Q, Zhao H, Shen J, Chen Z, Song W, Zheng P, Zhan S, Sun Y, Cai P, An K, Ouyang C, Zhao B, Zhou Q, Xu L, Xiong W, Zhang Z, Meng J, Chen J, Ma Y, Zhao H, Zhang M, Qu K, Hu J, Luo M, Xu F, Chen X, Xiong Y, Bao J, Xue T.
Cell.2022 Aug 18;185(17):3124-3137.e15. doi: 10.1016/j.cell.2022.07.009. Epub 2022 Aug 8. PMID: 35944541.

新たに発見されたカリウムチャネルロドプシンと５量体イオンチャネル

Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition.

Govorunova EG, Gou Y, Sineshchekov OA, Li H, Lu X, Wang Y, Brown LS, St-Pierre F, Xue M, Spudich JL.
Nat Neurosci.2022 Jul;25(7):967-974. doi: 10.1038/s41593-022-01094-6. Epub 2022 Jun 20. PMID: 35726059.

Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels.

Rozenberg A, Kaczmarczyk I, Matzov D, Vierock J, Nagata T, Sugiura M, Katayama K, Kawasaki Y, Konno M, Nagasaka Y, Aoyama M, Das I, Pahima E, Church J, Adam S, Borin VA, Chazan A, Augustin S, Wietek J, Dine J, Peleg Y, Kawanabe A, Fujiwara Y, Yizhar O, Sheves M, Schapiro I, Furutani Y, Kandori H, Inoue K, Hegemann P, Béjà O, Shalev-Benami M.
Nat Struct Mol Biol.2022 Jun;29(6):592-603. doi: 10.1038/s41594-022-00783-x. Epub 2022 Jun 16. PMID: 35710843.

ロドプシンのシグナル伝達を細胞膜の効果と共に観測することを可能とした

Capturing a rhodopsin receptor signalling cascade across a native membrane.

Chen S, Getter T, Salom D, Wu D, Quetschlich D, Chorev DS, Palczewski K,Robinson CV.
Nature.2022 Apr;604(7905):384-390. doi:10.1038/s41586-022-04547-x. Epub 2022 Apr 6.

眼球形態維持における光応答性神経節細胞の役割

Melanopsin modulates refractive development and myopia.

Chakraborty R, Landis EG, Mazade R, Yang V, Strickland R, Hattar S, Stone RA, Iuvone PM, Pardue MT.
Exp. Eye Res. (2022) 214, 108866.

The role of ipRGCs in ocular growth and myopia development.

Chakraborty R, Landis EG, Mazade R, Yang V, Strickland R, Hattar S, Stone RA, Iuvone PM, Pardue MT.
Exp. Eye Res. (2022) 214, 108866.

イオンチャネル型グルタミン酸受容体の開状態の構造やダイナミクス

Opening of glutamate receptor channel to subconductance levels.

Liu AL, Liu YF, Wang G, Shao YQ, Yu CX, Yang Z, Zhou ZR, Han X, Gong X, Qian KW, Wang LQ, Ma YY, Zhong YM, Weng SJ, Yang XL.
Sci. Adv.(2022) 8, eabm9027.

捕食から解放されたカメレオンがどのような体色変化をするか

Invasive chameleons released from predation display more conspicuous colors

Whiting MJ, Holland BS, Keogh JS, Noble DWA, Rankin KJ, Stuart-Fox D.
Sci Adv.May 13;8(19):eabn2415. doi: 10.1126/sciadv.abn2415. Epub 2022 May 11. PMID: 35544573.

ゼブラフィッシュ幼生の表面上皮細胞が、ゲノムを重複させずに細胞分裂を行う新たなメカニズムによって生物の成長に対応している

Skin cells undergo asynthetic fission to expand body surfaces in zebrafish

Chan KY, Yan CS, Roan HY, Hsu SC, Tseng TL, Hsiao CD, Hsu CP, Chen CH.
Nature. 2022 May;605(7908):119-125. doi: 10.1038/s41586-022-04641-0. Epub 2022 Apr 27. PMID: 35477758.

GPCR毎に独立したcAMPのナノドメインの形成

Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.

Anton SE, Kayser C, Maiellaro I, Nemec K, Möller J, Koschinski A, Zaccolo M, Annibale P, Falcke M, Lohse MJ, Bock A.
Cell. 2022 Mar 31;185(7):1130-1142.e11. doi: 10.1016/j.cell.2022.02.011. Epub 2022 Mar 15. PMID: 35294858.

蚊の色の認識とCO2の関係性

The olfactory gating of visual preferences to human skin and visible spectra in mosquitoes.

Alonso San Alberto D, Rusch C, Zhan Y, Straw AD, Montell C, Riffell JA.
Nat Commun. 2022 Feb 4;13(1):555. doi: 10.1038/s41467-022-28195-x. PMID: 35121739; PMCID: PMC8816903.

視細胞形態維持における錐体視物質の役割

Visual pigment-deficient cones survive and mediate visual signaling despite the lack of outer segments.

Xu H, Jin N, Chuang JZ, Zhang Z, Zhong X, Zhang Z, Sung CH, Ribelayga CP, Fu Y.
PNAS. 2022 Mar 1;119(9):e2115138119. doi: 10.1073/pnas.2115138119. PMID: 35197287; PMCID: PMC8892328.

ロドプシンの高い量子収率の原因を励起状態ダイナミクスからの理論的な解析

Quantum-classical simulations of rhodopsin reveal excited-state population splitting and its effects on quantum efficiency.

Yang X, Manathunga M, Gozem S, Léonard J, Andruniów T, Olivucci M.
Nat Chem. 2022 Apr;14(4):441-449. doi: 10.1038/s41557-022-00892-6. Epub 2022 Mar 3. PMID: 35241801 Free PMC article.

光応答性神経節細胞を介した急性の入眠制御メカニズム

The retinal ipRGC-preoptic circuit mediates the acute effect of light on sleep.

Zhang Z, Beier C, Weil T, Hattar S.
Nat Commun. 2021 Aug 25;12(1):5115. doi: 10.1038/s41467-021-25378-w. PMID: 34433830; PMCID: PMC8387462.