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2023

カリウム選択性チャネルロドプシンにおけるイオン選択性の分子的な基礎

Structural basis for ion selectivity in potassium-selective channelrhodopsins

Tajima S, Kim YS, Fukuda M, Jo Y, Wang PY, Paggi JM, Inoue M, Byrne EFX, Kishi KE, Nakamura S, Ramakrishnan C, Takaramoto S, Nagata T, Konno M, Sugiura M, Katayama K, Matsui TE, Yamashita K, Kim S, Ikeda H, Kim J, Kandori H, Dror RO, Inoue K, Deisseroth K, Kato HE.
Cell. 2023 Sep 28;186(20):4325-4344.e26. doi: 10.1016/j.cell.2023.08.009. Epub 2023 Aug 30.

高度に多重化された生物活性スクリーニングがヒトおよび微生物叢のメタボロームとGPCRomeの相互作用を明らかにする

Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions

Chen, H., Rosen, C. E., González-Hernández, J. A., Song, D., Potempa, J., Ring, A. M., & Palm, N. W.
Cell. 2023 Jul 6;186(14):3095-3110.e19. doi: 10.1016/j.cell.2023.05.024. Epub 2023 Jun 14. PMID: 37321219

Opn3は紫外線によってケラチノサイト核上にメラニンキャップが形成される反応を仲介する

Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formation

Lan Y, Zeng W, Wang Y, Dong X, Shen X, Gu Y, Zhang W, Lu H.
Commun Biol. 2023 Mar 3;6(1):238. doi: 10.1038/s42003-023-04621-8. PMID: 36869204

プロトンチャネルOTOP1は塩化アンモニウムの味覚センサーである

The proton channel OTOP1 is a sensor for the taste of ammonium chloride

Ziyu Liang, Courtney E Wilson, Bochuan Teng, Sue C Kinnamon, Emily R Liman
Nat Commun. 2023 Oct 5;14(1):6194. doi: 10.1038/s41467-023-41637-4. PMID: 37798269

キメラロドプシンの異所発現による視覚の回復と保護

Highly sensitive visual restoration and protection via ectopic expression of chimeric rhodopsin in mice

Katada Y, Yoshida K, Serizawa N, Lee D, Kobayashi K, Negishi K, Okano H, Kandori H, Tsubota K, Kurihara T.
iScience 2023 Aug 25;26(10):107716. doi: 10.1016/j.isci.2023.107716. eCollection 2023 Oct 20. PMID: 37720108

魚の体色の濃淡を光で制御するフィードバックメカニズム

Dynamic light filtering over dermal opsin as a sensory feedback system in fish color change.

Schweikert LE, Bagge LE, Naughton LF, Bolin JR, Wheeler BR, Grace MS, Bracken-Grissom HD, Johnsen S.
Nat Commun. 2023 Aug 22;14(1):4642. doi: 10.1038/s41467-023-40166-4. PMID: 37607908

ロドプシン細胞外ドメインへのナノボディへの結合による構造変化調節の構造基礎

Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain

Wu A, Salom D, Hong JD, Tworak A, Watanabe K, Pardon E, Steyaert J, Kandori H, Katayama K, Kiser PD, Palczewski K.
Nat Commun. 2023 Aug 25;14(1):5209. doi: 10.1038/s41467-023-40911-9.　PMID: 37626045

ショウジョウバエの網膜を動かす筋肉

Muscles that move the retina augment compound eye vision in Drosophila.

Fenk LM, Avritzer SC, Weisman JL, Nair A, Randt LD, Mohren TL, Siwanowicz I, Maimon G.
Nature 2022 Oct 26. doi: 10.1038/s41586-022-05317-5. Epub ahead of print. PMID: 36289333.

β2-adrenergic receptorのリガンド結合からGタンパク質との相互作用までの構造変化過程

The dynamics of agonist-β2-adrenergic receptor activation induced by binding of GDP-bound Gs protein

Amirhossein Mafi, Soo-Kyung Kim, William A Goddard 3rd
Nat. Chem. 2023 Jun 22. doi: 10.1038/s41557-023-01238-6. Online ahead of print. PMID: 37349378

眼での光受容が脂肪細胞の活性を制御するメカニズム

Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis

Meng JJ, Shen JW, Li G, Ouyang CJ, Hu JX, Li ZS, Zhao H, Shi YM, Zhang M, Liu R, Chen JT, Ma YQ, Zhao H, Xue T.
Cell 2023 Jan 19;186(2):398-412.e17. doi: 10.1016/j.cell.2022.12.024. PMID: 36669474

ショウジョウバエの磁気受容に必要な要素

Essential elements of radical pair magnetosensitivity in Drosophila

Bradlaugh AA, Fedele G, Munro AL, Hansen CN, Hares JM, Patel S, Kyriacou CP, Jones AR, Rosato E, Baines RA.
Nature 2023 Mar;615(7950):111-116. doi: 10.1038/s41586-023-05735-z. Epub 2023 Feb 22. PMID: 36813962

水溶性アデニル酸シクラーゼの急性阻害によるオンデマンドなオスの避妊

On-demand male contraception via acute inhibition of soluble adenylyl cyclase

Melanie Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W Myers, David J Huggins, Clemens Steegborn, Ileana C Miranda, Peter T Meinke, Jochen Buck, Lonny R Levin
Nat Commun 2023 Feb 14;14(1):637. doi: 10.1038/s41467-023-36119-6. PMID: 36788210

クラゲの視覚オプシンによりGタンパク質シグナル伝達の正確な時間制御が可能になる

A visual opsin from jellyfish enables precise temporal control of G protein signalling

Michiel van Wyk, Sonja Kleinlogel
Nat Commun 2023 Apr 28;14(1):2450. doi: 10.1038/s41467-023-38231-z PMID: 37117224

本質的に乱れたβ2アドレナリン受容体のC末端の機能とダイナミクス

Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor.

Heng, J., Hu, Y., Pérez-Hernández, G. et al.
Nat Commun 14, 2005 (2023). doi: 10.1038/s41467-023-37233-1 PMID: 37037825

頭足類の眼の発生が脊椎動物での神経発達に似た仕組みを示す

Cephalopod retinal development shows vertebrate-like mechanisms of neurogenesis

Napoli FR, Daly CM, Neal S, McCulloch KJ, Zaloga AR, Liu A, Koenig KM.
Curr. Biol. Dec 5;32(23):5045-5056.e3. doi: 10.1016/j.cub.2022.10.027. Epub 2022 Nov 9. PMID: 36356573

霊長類におけるOpn4の分子特性と機能

The spectral sensitivity of human circadian phase resetting and melatonin suppression to light changes dynamically with light duration.

St Hilaire MA, Ámundadóttir ML, Rahman SA, Rajaratnam SMW, Rüger M, Brainard GC, Czeisler CA, Andersen M, Gooley JJ, Lockley SW.
Proc Natl Acad Sci USA 2022 Dec 20;119(51):e2205301119. doi: 10.1073/pnas.2205301119. Epub 2022 Dec 12.

Encoding of environmental illumination by primate melanopsin neurons.

Liu A, Milner ES, Peng YR, Blume HA, Brown MC, Bryman GS, Emanuel AJ, Morquette P, Viet NM, Sanes JR, Gamlin PD, Do MTH.
Science 2023 Jan 27;379(6630):376-381. doi: 10.1126/science.ade2024. Epub 2023 Jan 26.

ロドプシンの超高速構造解析

Ultrafast structural changes direct the first molecular events of vision

Thomas Gruhl, Tobias Weinert, Matthew J Rodrigues, Christopher J Milne, Giorgia Ortolani, Karol Nass, Eriko Nango, Saumik Sen, Philip J M Johnson, Claudio Cirelli, Antonia Furrer, Sandra Mous, Petr Skopintsev, Daniel James, Florian Dworkowski, Petra Båth, Demet Kekilli, Dmitry Ozerov, Rie Tanaka, Hannah Glover, Camila Bacellar, Steffen Brünle, Cecilia M Casadei, Azeglio D Diethelm, Dardan Gashi, Guillaume Gotthard, Ramon Guixà-González, Yasumasa Joti, Victoria Kabanova, Gregor Knopp, Elena Lesca, Pikyee Ma, Isabelle Martiel, Jonas Mühle, Shigeki Owada, Filip Pamula, Daniel Sarabi, Oliver Tejero, Ching-Ju Tsai, Niranjan Varma, Anna Wach, Sébastien Boutet, Kensuke Tono, Przemyslaw Nogly, Xavier Deupi, So Iwata, Richard Neutze, Jörg Standfuss, Gebhard Schertler, Valerie Panneels
Nature 2023 Mar;615(7954):939-944. doi: 10.1038/s41586-023-05863-6. Epub 2023 Mar 22.

錐体視細胞サブタイプの違いを決める要因

Transcriptional control of cone photoreceptor diversity by a thyroid hormone receptor.

Aramaki M, Wu X, Liu H, Liu Y, Cho YW, Song M, Fu Y, Ng L, Forrest D.
Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2209884119. doi: 10.1073/pnas.2209884119. Epub 2022 Dec 1. PMID: 36454759.

視物質の時分割測定

Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature.

Dhankhar D, Salom D, Palczewski K, Rentzepis PM.
Proc Natl Acad Sci U S A.2023 Jan 3;120(1):e2214276120. doi: 10.1073/pnas.2214276120. Epub 2022 Dec 28. PMID: 36577071.

Comparison of Bovine and Carp Fish Visual Pigment Photo-Intermediates at Room Temperature.

Dhankhar D, Nagpal A, Tachibanaki S, Li R, Cesario TC, Rentzepis PM.
Photochem Photobiol.2022 Nov;98(6):1303-1311. doi: 10.1111/php.13621. Epub 2022 Apr 1. PMID: 35313014.

膜のイノシトールリン脂質がGPCRとアレスチンの相互作用を調節する

Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics.

Janetzko J, Kise R, Barsi-Rhyne B, Siepe DH, Heydenreich FM, Kawakami K, Masureel M, Maeda S, Garcia KC, von Zastrow M, Inoue A, Kobilka BK.
Cell. 2022 Nov 23;185(24):4560-4573.e19. doi: 10.1016/j.cell.2022.10.018. Epub 2022 Nov 10. PMID: 36368322.