2012

Infrared reception system of vertebrate TRP channels

Gracheva EO, Cordero-Morales JF, Gonzalez-Carcacia JA, Ingolia NT, Manno C, Aranguren CI, Weissman JS, Julius D.(2012) Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature. 2011 Aug 3;476(7358):88-91.

Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sanchez EE, Perez JC, Weissman JS, Julius D.(2012) Molecular basis of infrared detection by snakes. Nature. 2010 Apr 15;464(7291):1006-11.

Theoretical analysis of thermal activation mechanism of rhodopsin

Gozem S, Schapiro I, Ferre N, Olivucci M.(2012) The molecular mechanism of thermal noise in rod photoreceptors. Science. 2012 Sep 7;337(6099):1225-8.

The open-close mechanism of TRP/TRPL channels in microvillar of Drosophila

Roger C. Hardie, Kristian Franze.(2012) Photomechanical Responsese in Drosophila Photoreceptors. Science. 2012 Oct 12;338(6104):260-263.

The physiological functions of PAR2 and β-arrestin in the airway

Nichols HL, Saffeddine M, Theriot BS, Hegde A, Polley D, El-Mays T,(2012) b-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16660-5.

The essential amino acid residues for heteromerization of 5-HT2AR and mGluR2 and its function

Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuellar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, Lopez-Gimenez JF, Meana JJ, Benson DL, Gonzalez-Maeso J. (2012) Identification of Three Residues Essential for 5-HT2A-mGlu2 Receptor Heteromerization and its Psychoactive Behavioral Function. J Biol Chem. 2012 Nov 7(Epub).

Predicting an evolution of vertebrate eye by analyzing the functional moleculars present in photoreceptive organ of amphioxus

Vopalensky P, Pergner J, Liegertova M, Benito-Gutierrez E, Arendt D, Kozmik Z. (2012) Molecular analysis of the amphioxus frontal eye unravels the evolutionary origin of the retina and pigment cells of the vertebrate eye. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15383-8.

Photoreaction of Chlamydomonas histidine kinase rhodopsin (HKR1)

Luck M, Mathes T, Bruun S, Fudim R, Hagedorn R, Nguyen TM, Kateriya S, Kennis JT, Hildebrandt P, Hegemann P. (2012) A photochromic histidine kinase rhodopsin (HKR1) that is bimodally switched by UV and blue light. J Biol Chem. 2012 Oct 1(Epub).

A novel method using TACE for detecting GPCR activation

Inoue A, Ishiguro J, Kitamura H, Arima N, Okutani M, Shuto A, Higashiyama S, Ohwada T, Arai H, Makide K, Aoki J. (2012) TGFa shedding assay: an accurate and versatile method for detecting GPCR activation. Nat Methods 2012 Oct;9(10):1021-9.

Structural dynamics of PYP in its photocycle

Kim TW, Lee JH, Choi J, Kim KH, van Wilderen LJ, Guerin L, Kim Y, Jung YO, Yang C, Kim J, Wulff M, van Thor JJ, Ihee H. (2012) Protein structural dynamics of photoactive yellow protein in solution revealed by pump-probe X-ray solution scattering. J Am Chem Soc. 2012 Feb 15;134(6):3145-53.

Tripathi S, Srajer V, Purwar N, Henning R, Schmidt M. (2012) pH dependence of the photoactive yellow protein photocycle investigated by time-resolved crystallography. Biophys J. 2012 Jan 18;102(2):325-32.

Function of RPE65 in cone photoreceptor cells

Tang PH, Buhusi MC, Ma JX, Crouch RK. (2011) RPE65 is present in human green/red cones and promotes photopigment regeneration in an in vitro cone cell model. J Neurosci. 2011 Dec 14;31(50):18618-26.

Tang PH, Wheless L, Crouch RK. (2011) Regeneration of photopigment is enhanced in mouse cone photoreceptors expressing RPE65 protein. J Neurosci. 2011 Jul 13;31(28):10403-11.

Memory recall by light irradiation using channelrhodopsin ChR2 expressing in hippocampal engram

Liu X, Ramirez S, Pang PT, Puryear CB, Govindarajan A, Deisseroth K, Tonegawa S. (2012) Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature 2012 Mar 22;484(7394):381-5.

Deficiency of cyclic nucleotide-gated channel induces endoplasmic reticulum stress and results in cone photoreceptor degeneration.

Thapa A, Morris L, Xu J, Ma H, Michalakis S, Biel M, Ding XQ. (2012) Endoplasmic Reticulum Stress-associated Cone Photoreceptor Degeneration in Cyclic Nucleotide-gated Channel Deficiency. J Biol Chem. 2012 May 25;287(22):18018-29.

Restoration of vision by transplantation of photoreceptor cells

Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UF, Benucci A, Sung CH, Bainbridge JW, Carandini M, Yau KW, Sowden JC, Ali RR. (2012) Restoration of vision after transplantation of photoreceptors. Nature 2012 May 3;485(7396):99-103.

Change of the conformational ensemble of G protein-coupled receptors by binding ligands and signaling proteins

Mary S, Damian M, Louet M, Floquet N, Fehrentz JA, Marie J, Martinez J, Baneres JL. (2012) Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8304-9.

Inhibition mechanism of stimulatory G protein signaling by prostaglandin E2 receptor in heart

Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. (2012) Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6578-83.

Molecular mechanism of GPCR activation by biased ligands

Rahmeh R, Damian M, Cottet M, Orcel H, Mendre C, Durroux T, Sharma KS, Durand G, Pucci B, Trinquet E, Zwier JM, Deupi X, Bron P, Baneres JL, Mouillac B, Granier S. (2012) Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6733-8.

Relationship between expression of OPN3 and apoptosis in hepatocellular caarcinoma cells

Jiao J, Hong S, Zhang J, Ma L, Sun Y, Zhang D, Shen B, Zhu C. (2012) Opsin3 sensitizes hepatocellular carcinoma cells to 5-fluorouracil treatment by regulating the apoptotic pathway. Cancer Lett. 2012 Jul 1;320(1):96-103.

Structural change and dynamics of beta2 adrenergic receptor and Gs

Chung KY, Rasmussen SG, Liu T, Li S, DeVree BT, Chae PS, Calinski D, Kobilka BK, Woods VL Jr, Sunahara RK. (2011) Conformational changes in the G protein Gs induced by the beta2 adrenergic receptor. Nature. 2011 Sep 28;477(7366):611-5.

Bockenhauer S, Furstenberg A, Yao XJ, Kobilka BK, Moerner WE. (2011) Conformational dynamics of single G protein-coupled receptors in solution. J Phys Chem B. 2011 Nov 17;115(45):13328-38.

Exploring of the role of layer 6 in cortical circuits of vision with the channelrhodopsin ChR2

Olsen SR, Bortone DS, Adesnik H, Scanziani M. (2012) Gain control by layer six in cortical circuits of vision. Nature. 2012 Feb 22;483(7387):47-52.

Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans.

Salom D, Cao P, Sun W, Kramp K, Jastrzebska B, Jin H, Feng Z, Palczewski K. (2012) Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans. FASEB J. Epub 2011 Nov 16.

Rhodopsin 5- and Rhodopsin 6-Mediated Clock Synchronization in Drosophila melanogaster is Independent of Retinal Phospholipase C-β Signaling.

Szular J, Sehadova H, Gentile C, Szabo G, Chou WH, Britt SG, Stanewsky R. (2012) Rhodopsin 5- and Rhodopsin 6-Mediated Clock Synchronization in Drosophila melanogaster is Independent of Retinal Phospholipase C-β Signaling. J Biol Rhythms. Epub 2012 Feb 27.

Genetic dissection reveals two separate retinal substrates for polarization vision in Drosophila.

Wernet MF, Velez MM, Clark DA, Baumann-Klausener F, Brown JR, Klovstad M, Labhart T, Clandinin TR. (2012) Genetic dissection reveals two separate retinal substrates for polarization vision in Drosophila. Curr Biol. Epub 2011 Dec 15.

Weir PT, Dickinson MH. (2012) Flying Drosophila orient to sky polarization. Curr Biol. Epub 2011 Dec 15.

XPORT-Dependent Transport of TRP and Rhodopsin

Rosenbaum EE, Brehm KS, Vasiljevic E, Liu CH, Hardie RC, Colley NJ. (2011) XPORT-Dependent Transport of TRP and Rhodopsin Neuron. Epub 2011 Nov 17.

Melanopsin signalling in mammalian iris and retina.

Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW. (2011) Melanopsin signalling in mammalian iris and retina. Nature. Epub 2011 Nov 2.

NaV1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms.

Han S, Yu FH, Schwartz MD, Linton JD, Bosma MM, Hurley JB, Catterall WA, de la Iglesia HO.　(2012) NaV1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms. Proc Natl Acad Sci U S A. Epub 2012 Jan 5.

Anti-/Pro-psychotic drug signaling via 5-HT2AR/mGluR2 heterodimers

Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD Jr, Brezina V, Sealfon SC, Filizola M, Gonzalez-Maeso J, Logothetis DE. (2011) Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell. 2011 Nov 23;147(5):1011-23.

Gonzalez-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, Lopez-Gimenez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana JJ, Sealfon SC. (2011) Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature. Epub 2008 Feb 24.

Molecular mechanisms of disease for mutations at Gly-90 in rhodopsin

Toledo D, Ramon E, Aguila M, Cordomi A, Perez JJ, Mendes HF, Cheetham ME, Garriga P. (2011) Molecular mechanisms of desease for mutations at Gly-90 in rhodopsin. J Biol Chem. Epub 2011 Sep 22.