2016

　　　

初期アルツハイマー病の記憶状態を光遺伝学的手法(チャネルロドプシン２）を用いて操作する

Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease.

Roy DS, Arons A, Mitchell TI, Pignatelli M, Ryan TJ, Tonegawa S
Nature 2016 MMar 24;531(7595):508-12.

クロライドイオンを透過して興奮を抑える新規チャネルロドプシン

Photochemical reaction cycle transitions during anion channelrhodopsin gating.

Sineshchekov OA, Li H, Govorunova EG, Spudich JL
Proc Natl Acad Sci U S A. 2016 Mar 21. pii: 201525269. [Epub ahead of print]

Gating mechanisms of a natural anion channelrhodopsin.

Sineshchekov OA, Govorunova EG, Li H, Spudich JL
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14236-41.

NEUROSCIENCE. Natural light-gated anion channels: A family of microbial rhodopsins for advanced optogenetics.

Govorunova EG, Sineshchekov OA, Janz R, Liu X, Spudich JL
Science. 2015 Aug 7;349(6248):647-50.

rodとconeの拮抗に基づく新しい色覚神経回路

A neuronal circuit for colour vision based on rod-cone opponency.

Joesch M, Meister M
Nature. 2016 Apr 14;532(7598):236-9.

昆虫のオプシンの多様性について

Conservation, Duplication, and Divergence of Five Opsin Genes in Insect Evolution

Feuda R, Marlétaz F, Bentley MA, Holland PW
Genome Biol Evol. 2016 Feb 9;8(3):579-87.

Extraordinary diversity of visual opsin genes in dragonflies

Futahashi R, Kawahara-Miki R, Kinoshita M, Yoshitake K, Yajima S, Arikawa K, Fukatsu T
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1247-56.

アレスチンの構造変化と下流シグナルの活性化の関係性

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle.

Nuber S, Zabel U, Lorenz K, Nuber A, Milligan G, Tobin AB, Lohse MJ, Hoffmann C
Nature. 2016 Mar 31;531(7596):661-4.

β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation

Eichel K, Jullié D, von Zastrow M
Nat Cell Biol. 2016 Mar;18(3):303-10.

ゼブラフィッシュ幼生の視蓋ニューロンにおける視覚刺激、聴覚刺激、水流刺激への応答

Functional Profiles of Visual-, Auditory-, and Water Flow-Responsive Neurons in the Zebrafish Tectum

Thompson AW, Vanwalleghem GC, Heap LA, Scott EK
Curr Biol. 2016 Mar 21;26(6):743-54.

クリプトクロムによる磁気受容がコンパスの役割を果たす

Cryptochrome 2 mediates directional magnetoreception in cockroaches

Bazalova O, Kvicalova M, Valkova T, Slaby P, Bartos P, Netusil R, Tomanova K, Braeunig P, Lee HJ, Sauman I, Damulewicz M, Provaznik J, Pokorny R, Dolezel D, Vacha M
Proc Natl Acad Sci U S A.2016 Feb 9;113(6):1660-5.

Lampreyの視細胞に関する研究

Single-photon sensitivity of lamprey rods with cone-like outer segments

Morshedian A, Fain GL
Curr Biol.2015 Feb 16;25(4):484-7.

A Cambrian origin for vertebrate rods

Asteriti S, Grillner S, Cangiano L
Elife.2015 Jun 22;4.

Evolution of Vertebrate Phototransduction: Cascade Activation

Lamb TD, Patel H, Chuah A, Natoli RC, Davies WI, Hart NS, Collin SP, Hunt DM
Mol Biol Evol.2016 Aug;33(8):2064-87.

NMRを用いたA2Aアデノシン受容体の様々なリガンドに対応する構造の解析

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

Ye L, Van Eps N, Zimmer M, Ernst OP, Prosser RS
Nature.2016 May 12;533(7602):265-8.

真正細菌のイオンポンプ形ロドプシン非対称機能変換

Asymmetric Functional Conversion of Eubacterial Light-driven Ion Pumps

Inoue K, Nomura Y, Kandori H
J Biol Chem.2016 May 6;291(19):9883-93.

光逃避行動に寄与していると考えられている脳内のOPN5についての電気生理学的解析

Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles

Currie SP, Doherty GH, Sillar KT
Proc Natl Acad Sci U S A.2016 May 24;113(21):6053-8.