2011

レーバー先天性黒内障に見られる錐体視物質の機能喪失には錐体オプシンが関わる

Zhang T, Zhang N, Baehr W, Fu Y. (2011) Cone opsin determines the time course of cone photoreceptor degeneration in Leber congenital amaurosis. Proc Natl Acad Sci U S A. Epub 2011 May 9.

ショウジョウバエにおける温度認識メカニズム

Gallio M, Ofstad TA, Macpherson LJ, Wang JW, Zuker CS. (2011) The coding of temperature in the Drosophila brain. Cell. 2011 Feb. 18;144(4):614-24.

機能を保持した安定な状態でGPCRを発現・精製する手法

Corin K, Baaske P, Ravel DB, Song J, Brown E, Wang X, Geissler S, Wienken CJ, Jerabek-Willemsen M, Duhr S, Braun D, Zhang S. (2011) A robust and rapid method of producing soluble, stable, and functional G-protein coupled receptors. PLoS One. 2011;6(10):e23036.

Thompson AA, Liu JJ, Chun E, Wacker D, Wu H, Cherezov V, Stevens RC. (2011) GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles. Methods. 2011 Oct 21.

哺乳類OPN5の生体内の局在および分子機能

Kojima D, Mori S, Torii M, Wada A, Morishita R, Fukada Y. (2011) UV-Sensitive Photoreceptor Protein OPN5 in Humans and Mice. PLoS One. 2011;6(10):e26388.

Nieto PS, Valdez DJ, Acosta-Rodriguez VA, Guido ME. (2011) Expression of Novel Opsins and Intrinsic Light Responses in the Mammalian Retinal Ganglion Cell Line RGC-5. Presence of OPN5 in the Rat Retina. PLoS One. 2011;6(10):e26417.

ロドプシンとアレスチンの結合に伴うロドプシンの第8へリックスの揺らぎの変化

Kirchberg K, Kim TY, Moller M, Skegro D, Dasara Raju G, Granzin J, Buldt G, Schlesinger R, Alexiev U. (2011) Conformational dynamics of helix 8 in the GPCR rhodopsin controls arrestin activation in the desensitization process. Proc Natl Acad Sci U S A. Epub 2011 Oct 28.

ロドプシンの熱反応におけるレチナール熱異性化およびシッフ塩基加水分解の反応解析

Liu J, Liu MY, Nguyen JB, Bhagat A, Mooney V, Yan EC. (2009) Thermal decay of rhodopsin: role of hydrogen bonds in thermal isomerization of 11-cis retinal in the binding site and hydrolysis of protonated Schiff base. J Am Chem Soc. 2009 Jul 1;131(25):8750-1.

Liu J, Liu MY, Fu L, Zhu GA, Yan EC. (2011) Chemical kinetic analysis of thermal decay of rhodopsin reveals unusual energetics of thermal isomerization and hydrolysis of schiff base. J Biol Chem. 2011 Nov 4;286(44):38408-16.

ゼブラフィッシュにおけるメラノプシンの網膜発現パターンおよび機能の解析

Davies WI, Zheng L, Hughes S, Tamai TK, Turton M, Halford S, Foster RG, Whitmore D, Hankins MW. (2011) Functional diversity of melanopsins and their global expression in the teleost retina. Cell Mol Life Sci. Epub 2011 Aug 11.

ロドプシンとトランスデューシンの相互作用のキネティクス解析

Dell'orco D, Koch KW. (2011) A dynamic scaffolding mechanism for rhodopsin and transducin interaction in vertebrate vision. Biochem J. Epub 2011 Aug 15.

ロドプシン二量体とトランスデューシンの複合体の構造解析

Jastrzebska B, Ringler P, Lodowski DT, Moiseenkova-Bell V, Golczak M, Muller SA, Palczewski K, Engel A. (2011) Rhodopsin-transducin heteropentamer: Three-dimensional structure and biochemical characterization. J Struct Biol. Epub 2011 Sep 6.

代謝型グルタミン酸受容体の活性化におけるシステインリッチドメインの役割

Huang S, Cao J, Jiang M, Labesse G, Liu J, Pin JP, Rondard P. (2011) Interdomain movements in metabotropic glutamate receptor activation. Proc Natl Acad Sci U S A. Sep 13;108(37):15480-5.

味覚修飾物質ミラクリンの甘味受容体に対する作用機構

Koizumi A, Tsuchiya A, Nakajima KI, Ito K, Terada T, Shimizu-Ibuka A, Briand L, Asakura T, Misaka T, Abe K. (2011) Human sweet taste receptor mediates acid-induced sweetness of miraculin. Proc Natl Acad Sci U S A. Epub 2011 Sep 26.

アドレナリン受容体とGsの複合体の結晶構造

Rasmussen SG, Devree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK. (2011) Crystal structure of the β(2) adrenergic receptor-Gs protein complex. Nature Epub 2011 Jul 19.

UNC119によるトランスデューシンの細胞内輸送

Gopalakrishna KN, Doddapuneni K, Boyd KK, Masuho I, Martemyanov KA, Artemyev NO. (2011) Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors. J Biol Chem. Epub 2011 Jun 28.

視物質の熱による活性化は発色団の熱異性化によるものである

Luo DG, Yue WW, Ala-Laurila P, Yau KW. (2011) Activation of visual pigments by light and heat. Science. Jun 10;332(6035):1307-12.

翻訳後修飾酵素Rce1が視細胞におけるPDEの輸送に必要である

Christiansen JR, Kolandaivelu S, Bergo MO, Ramamurthy V. (2011) RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments. Proc Natl Acad Sci U S A. May 24;108(21):8862-6. Epub 2011 May 9.

活性化ロドプシン密度に依存したアレスチン結合の量的解析

Sommer ME, Hofmann KP, Heck M. (2011) Arrestin-rhodopsin binding stoichiometry in isolated rod outer segment membranes depends on the percentage of activated receptors. J Biol Chem. Mar 4;286(9):7359-69. Epub 2010 Dec 17.

Gタンパク質アルファサブユニットのdominant-negative変異体(S43N)の機能解析

Ramachandran S, Cerione RA. (2011) A dominant-negative Galpha mutant that traps a stable rhodopsin-Galpha-GTP-betagamma complex. J Biol Chem. Apr 8;286(14):12702-11. Epub 2011 Feb 1.

松果体によるゼブラフィッシュの背景色応答の制御

Zhang C, Song Y, Thompson DA, Madonna MA, Millhauser GL, Toro S, Varga Z, Westerfield M, Gamse J, Chen W, Cone RD. (2010) Pineal-specific agouti protein regulates teleost background adaptation. Proc Natl Acad Sci U S A. Nov 23;107(47):20164-71. Epub 2010 Oct 27.

ショウジョウバエの温度調節にロドプシンが機能する

Shen WL, Kwon Y, Adegbola AA, Luo J, Chess A, Montell C. (2011) Function of rhodopsin in temperature discrimination in Drosophila. Science. Epub 2011 Mar 11.

レチナールシッフ塩基の加水分解におけるバルク水の役割

Jastrzebska B, Palczewski K, Golczak M. (2011) Role of bulk water in the hydrolysis of rhodopsin's chromophore. J Biol Chem. Epub 2011 Apr 1.

ロドプシンの活性化およびGタンパク質との相互作用におけるTyr223の役割

Elgeti M, Kazmin R, Heck M, Morizumi T, Ritter E, Scheerer P, Ernst OP, Siebert F, Hofmann KP, Bartl FJ. (2011) Conserved tyr223(5.58) plays different roles in the activation and g-protein interaction of rhodopsin. J Am Chem Soc. Epub 2011 Apr 20.

アレスチンにおけるGPCRとの結合に重要なアミノ酸残基の探索

Vishnivetskiy SA, Gimenez LE, Francis DJ, Hunson SM, Hubbell WL, Klug CS, Gurevich VV. (2011) Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins. J Biol Chem. Epub 2011 Apr 6.

ショウジョウバエにおけるクリプトクロムの光活性化

Fogle KJ, Parson KG, Dahm NA, Holmes TC. (2011) CRYPTOCHROME is a blue-light sensor that regulates neuronal firing rate. Science. 2011 Mar 18;331(6023):1409-13. Epub 2011 Mar 3.

メタロドプシンIIの結晶構造

Choe HW, Kim YJ, Park JH, Morizumi T, Pai EF, Kraus N, Hofmann KP, Scheerer P, Ernst OP. (2011) Crystal structure of metarhodopsin II. Nature. 2011 Mar 31;471(7340):651-655. Epub 2011 Mar 9.

Standfuss J, Edwards PC, D'Antona A, Fransen M, Xie G, Oprian DD, Schertler GF. (2011) The structural basis of agonist-induced activation in constitutively active rhodopsin. Nature. 2011 Mar 31;471(7340):656-60. Epub 2011 Mar 9.