2014

桿体視細胞のリニューアル機構のメカニズム

Light regulates the ciliary protein transport and outer segment disc renewal of Mammalian photoreceptors

Hsu YC, Chuang JZ, Sung CH
Dev Cell. 2015 Mar 23;32(6):731-42.

アドレナリン受容体とアンジオテンシン受容体はヘテロダイマーを形成する

Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling

Bellot M, Galandrin S, Boularan C, Matthies HJ, Despas F, Denis C, Javitch J, Mazères S, Sanni SJ, Pons V, Seguelas MH, Hansen JL, Pathak A, Galli A, Sénard JM, Galés C
Nat Chem Biol. 2015 Apr;11(4):271-9.

UV感受性錐体視物質の熱活性化機構

Kinetics of thermal activation of an ultraviolet cone pigment

Mooney V, Sekharan S, Liu J, Guo Y, Batista VS, Yan EC
J Am Chem Soc. 2015 Jan 14;137(1):307-13.

メダカの配偶者防衛行動にバソトシンが寄与する

An essential role of the arginine vasotocin system in mate-guarding behaviors in triadic relationships of medaka fish (Oryzias latipes)

Yokoi S, Okuyama T, Kamei Y, Naruse K, Taniguchi Y, Ansai S, Kinoshita M, Young LJ, Takemori N, Kubo T, Takeuchi H
PLoS Genet. 2015 Feb 26;11(2):e1005009.

RPE65の結晶構造

Catalytic mechanism of a retinoid isomerase essential for vertebrate vision

Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K
Nat Chem Biol. 2015 Jun;11(6):409-15.

ショウジョウバエ視細胞におけるIP3とCa2+の役割

Functional cooperation between the IP3 receptor and phospholipase C secures the high sensitivity to light of Drosophila photoreceptors in vivo

Kohn E, Katz B, Yasin B, Peters M, Rhodes E, Zaguri R, Weiss S, Minke B
J Neurosci. 2015 Feb 11;35(6):2530-46.

光でダイマー化する蛋白質を用いたオプトジェネティクス・ツールの開発

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

Guntas G, Hallett RA, Zimmerman SP, Williams T, Yumerefendi H, Bear JE, Kuhlman B
Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):112-7.

Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins

Kawano F, Suzuki H, Furuya A, Sato M
Nat Commun. 2015 Feb 24;6:6256.

マウス錐体におけるリカバリン・GRK1による光応答調節

Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase

Sakurai K, Chen J, Khani SC, Kefalov VJ
J Biol Chem. 2015 Apr 3;290(14):9239-50.

ドーパミン受容体(D2R)のbiased変異体の作製とその応用

Elucidation of G-protein and β-arrestin functional selectivity at　the dopamine D2 receptor

Peterson SM, Pack TF, Wilkins AD, Urs NM, Urban DJ, Bass CE, Lichtarge O, Caron MG
Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7097-102.

眼の起源に関する研究

Eye-like ocelloids are built from different endosymbiotically acquired components

Gavelis GS, Hayakawa S, White RA 3rd, Gojobori T, Suttle CA, Keeling PJ, Leander BS
Nature. 2015 Jul 9;523(7559):204-7.

Function and Evolutionary Origin of Unicellular Camera-Type Eye Structure

Hayakawa S, Takaku Y, Hwang JS, Horiguchi T, Suga H, Gehring W, Ikeo K, Gojobori T
PLoS One. 2015 Mar 3;10(3):e0118415.

エストロゲン受容体とカルシウムポンプの相互作用

Hetero-oligomeric Complex between the G Protein-coupled Estrogen Receptor 1 and the Plasma Membrane Ca2+-ATPase 4b

Tran QK, VerMeer M, Burgard MA, Hassan AB, Giles J
J Biol Chem. 2015 May 22;290(21):13293-307.

共有結合を形成して機能するペプチドタグと認識タンパク質のペア、SpyTag/SpyCatcherに関する研究

Peptide tag forming a rapid covalent bond to a protein, through　engineering a bacterial adhesin.

Zakeri B, Fierer JO, Celik E, Chittock EC, Schwarz-Linek U, Moy VT, Howarth M
Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):E690-7.

Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo.

Bedbrook CN, Kato M, Ravindra Kumar S, Lakshmanan A, Nath RD, Sun F, Sternberg PW, Arnold FH, Gradinaru V
Chem Biol. 2015 Aug 20;22(8):1108-21.

ゴカイのGo-opsinの分子特性と生理機能への関わり

Spectral Tuning of Phototaxis by a Go-Opsin in the Rhabdomeric Eyes of Platynereis.

Gühmann M, Jia H, Randel N, Verasztó C, Bezares-Calderón LA, Michiels NK, Yokoyama S, Jékely G
Curr Biol. 2015 Aug 31;25(17):2265-71.

ショウジョウバエの睡眠覚醒サイクルを調節することに関わる細胞膜の興奮性の実態

A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability.

Flourakis M, Kula-Eversole E, Hutchison AL, Han TH, Aranda K, Moose DL, White KP, Dinner AR, Lear BC, Ren D, Diekman CO, Raman IM, Allada R
Cell. 2015 Aug 13;162(4):836-48.

ロドプシンとβ2アドレナリン受容体のキメラ受容体opto-β2ARの分子特性とその応用

Optodynamic simulation of β-adrenergic receptor signalling.

Siuda ER, McCall JG, Al-Hasani R, Shin G, Il Park S, Schmidt MJ, Anderson SL, Planer WJ, Rogers JA, Bruchas MR
Nat Commun. 2015 Sep 28;6:8480.

レチナールアナログを用いた微生物型ロドプシンのオプトジェネティクスへの応用

Synthetic retinal analogues modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools.

AzimiHashemi N, Erbguth K, Vogt A, Riemensperger T, Rauch E, Woodmansee D, Nagpal J, Brauner M, Sheves M, Fiala A, Kattner L, Trauner D, Hegemann P, Gottschalk A, Liewald JF
Nat Commun. 2014 Dec 15;5:5810.

膜電位がβ1アドレナリン受容体のアゴニストのefficacyを調整する

Membrane Potential Controls the Efficacy of Catecholamine-induced β1-Adrenoceptor Activity.

Birk A, Rinne A, Bünemann M
J Biol Chem. 2015 Nov 6;290(45):27311-20.

ipRGCの視覚機能への関わり

Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn.

Storchi R, Milosavljevic N, Eleftheriou CG, Martial FP, Orlowska-Feuer P, Bedford RA, Brown TM, Montemurro MA, Petersen RS, Lucas RJ
Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5734-43.

分子系統樹の解析に基づいたロドプシンの分子特性の解析

The molecular origin and evolution of dim-light vision in mammals.

Bickelmann C, Morrow JM, Du J, Schott RK, van Hazel I, Lim S, Müller J, Chang BS
Evolution. 2015 Nov;69(11):2995-3003.

Spectral Tuning of Killer Whale (Orcinus orca) Rhodopsin: Evidence for Positive Selection and Functional Adaptation in a Cetacean Visual Pigment.

Dungan SZ, Kosyakov A, Chang BS
Mol Biol Evol. 2016 Feb;33(2):323-36.

β2アドレナリン受容体の構造平衡の一分子計測

Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR.

Lamichhane R, Liu JJ, Pljevaljcic G, White KL, van der Schans E, Katritch V, Stevens RC, Wüthrich K, Millar DP
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14254-9.

レチナールのA1-A2スイッチ(Rhodopsin-Porphyropsin switch)に関わる酵素発見

Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.

Enright JM, Toomey MB, Sato SY, Temple SE, Allen JR, Fujiwara R, Kramlinger VM, Nagy LD, Johnson KM, Xiao Y, How MJ, Johnson SL, Roberts NW, Kefalov VJ, Guengerich FP, Corbo JC
Curr Biol. 2015 Dec 7;25(23):3048-57.

甲殻類の偏光感知はどのような生理機能に関わっているか

Target Detection Is Enhanced by Polarization Vision in a Fiddler Crab.

How MJ, Christy JH, Temple SE, Hemmi JM, Marshall NJ, Roberts NW
Curr Biol. 2015 Dec 7;25(23):3069-73.

Circularly Polarized Light as a Communication Signal in Mantis Shrimps.

Gagnon YL, Templin RM, How MJ, Marshall NJ
Curr Biol. 2015 Dec 7;25(23):3074-8.

紫外線の生理作用

Skin β-endorphin mediates addiction to UV light.

Fell GL, Robinson KC, Mao J, Woolf CJ, Fisher DE
Cell. 2014 Jun 19;157(7):1527-34.

ヘビ視細胞の”transmutation theory”

Evolutionary transformation of rod photoreceptors in the all-cone retina of a diurnal garter snake.

Schott RK, Müller J, Yang CG, Bhattacharyya N, Chan N, Xu M, Morrow JM, Ghenu AH, Loew ER, Tropepe V, Chang BS
Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):356-61.

Multiple rod-cone and cone-rod photoreceptor transmutations in snakes: evidence from visual opsin gene expression.

Simões BF, Sampaio FL, Loew ER, Sanders KL, Fisher RN, Hart NS, Hunt DM, Partridge JC, Gower DJ
Proc Biol Sci. 2016 Jan 27;283(1823).

哺乳類のipRGCの機能多様性

Isoforms of Melanopsin Mediate Different Behavioral Responses to Light.

Jagannath A, Hughes S, Abdelgany A, Pothecary CA, Di Pretoro S, Pires SS, Vachtsevanos A, Pilorz V, Brown LA, Hossbach M, MacLaren RE, Halford S, Gatti S, Hankins MW, Wood MJ, Foster RG, Peirson SN
Curr Biol. 2015 Sep 21;25(18):2430-4.

All spiking, sustained ON displaced amacrine cells receive gap-junction input from melanopsin ganglion cells.

Reifler AN, Chervenak AP, Dolikian ME, Benenati BA, Li BY, Wachter RD, Lynch AM, Demertzis ZD, Meyers BS, Abufarha FS, Jaeckel ER, Flannery MP, Wong KY
Curr Biol. 2015 Nov 2;25(21):2763-73.